The international HAE guideline under real-life conditions: From possibilities to limits in daily life - current real-world data of 8 German angioedema centers.

Background And Objectives: Patients with rare diseases like hereditary angioedema (HAE) are usually referred to an angioedema center to ensure guideline-compliant and experience-based therapy. Even though there are established guidelines and several approved therapeutics, there are still open questions and situations in the daily care of HAE patients, where an exchange between centers is needed.

Materials And Methods: A survey was conducted among physicians from German angioedema centers regarding challenges and issues in everyday HAE treatment.

Biologic therapy for chronic spontaneous urticaria in pediatrics and adolescents: current landscape, challenges, and future perspectives.

Introduction: Chronic spontaneous urticaria (CSU) poses significant challenges, especially in pediatric and adolescent patients, impacting physical, emotional, and social well-being. Recent biologic breakthroughs offer promise, however, data on safety and efficacy in this population remain limited.

Areas Covered: This review examines current biologic treatments in pediatrics and adolescents with CSU and explores the rapidly emerging landscape.

Synthesis of the fluorohydridoborate anions [BHF] and [1-HFB-9,12-X-closo-1,2-CBH] (X = H, I): deboronation of 1,2- and 1,7-dicarba-closo-dodecaboranes with anhydrous [MeN]F.

Deboronation of closo-1,7-CBH and 1-R-closo-1,2-CBH (R = Me, Ph) with anhydrous [MeN]F yields [MeN][BHF] that is the first structurally characterized anion of the series [BHF] (x = 1-3). Deboronation of 9,12-R-closo-1,7-CBH (R = H, I) gives a mixture of [MeN][BHF] and [MeN][1-HFB-9,12-R-closo-1,2-CBH].