Publications by authors named "Katey Ss Enfield"
Article Synopsis
- Increased levels and variety of human endogenous retrovirus (HERV) transcription are found in many cancer types and are associated with disease outcomes, although the mechanisms are not fully understood.
- The study identified that higher transcription of HERVH in lung squamous cell carcinoma (LUSC) is linked to patient survival and is driven by a CALB1 isoform influenced by HERVH, which begins to express in early preinvasive stages.
- While calbindin (the protein encoded by CALB1) promotes growth in LUSC, its absence triggers cellular senescence and affects the cancer environment by altering the secretion of factors like CXCL8, leading to increased neutrophil presence and poorer patient prognosis in advanced tumors
T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown.
View Article and Find Full Text PDFArsenic is a well-known human carcinogen, which potentially affects ~160 million people worldwide via exposure to unsafe levels in drinking water. Lungs are one of the main target organs for arsenic-related carcinogenesis. These tumors exhibit particular features, such as squamous cell-type specificity and high incidence among never smokers.
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