The Functions of N-Methyladenosine in Nuclear RNAs.

N-methyladenosine (mA) is one of the most common modifications in both eukaryotic and prokaryotic mRNAs. It has been experimentally confirmed that mA methylation is involved in the regulation of stability and translation of various mRNAs. Until recently, the majority of mA-related studies have been focused on the cytoplasmic functions of this modification.

Analyzing the Effects of Single Nucleotide Polymorphisms on hnRNPA2/B1 Protein Stability and Function: Insights for Anticancer Therapeutic Design.

Heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) is a pivotal player in m6A recognition, RNA metabolism, and antiviral responses. In the context of cancer, overexpression of hnRNPA2/B1, abnormal RNA levels, and m6A depositions are evident. This study focuses on two significant nonsynonymous single nucleotide polymorphisms (nsSNPs) within hnRNPA2/B1, namely, F66L and E92K.