Publications by authors named "Katerina Dvorakova Bendova"
Peptides that form transmembrane barrel-stave pores are potential alternative therapeutics for bacterial infections and cancer. However, their optimization for clinical translation is hampered by a lack of sequence-function understanding. Recently, we have designed the first synthetic barrel-stave pore-forming antimicrobial peptide with an identified function of all residues.
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- Siderophores are small molecules produced by microbes that help them acquire iron, and when radiolabelled with gallium-68, they can be used for targeted imaging of infections via PET.
- The study focused on two siderophore isomers, ferrirubin (FR) and ferrirhodin (FRH), which showed different properties in terms of hydrophilicity, protein binding, and pharmacokinetics after being labelled with gallium-68.
- Both siderophores effectively targeted bacteria in a mouse model, demonstrating their potential for infection imaging, with FR exhibiting faster clearance and lower blood retention compared to FRH.