Publications by authors named "Katelyn Tondo-Steele"
Article Synopsis
- * In a seven-year retrospective study, 91 USC patients were analyzed, with nearly half referred for genetic counseling; 56% of these underwent genetic testing.
- * Findings revealed 12.5% of tested patients had pathogenic variants, and 16.6% had variants of unknown significance, leading to a recommendation for standardizing genetic testing in USC management.
Article Synopsis
- A study was conducted to evaluate how patient and procedural factors affect opioid use after vulvar surgery in gynecologic oncology, aiming to create a personalized opioid prescribing guideline.
- The retrospective analysis included 100 patients, revealing that 35% did not need any opioids post-surgery, while 39% used opioids, and 26% did not use their prescribed opioids.
- Age significantly influenced opioid usage, and although NSAID contraindications weren’t statistically significant, they were important in developing the final prescribing guidelines.
Objective: A quality improvement initiative (QII) was conducted with five community-based health systems' oncology care centers (sites A-E). The QII aimed to increase referrals, genetic counseling (GC), and germline genetic testing (GT) for patients with ovarian cancer (OC) and triple-negative breast cancer (TNBC).
Methods: QII activities occurred at sites over several years, all concluding by December 2020.
The objective of this review is to explore the metabolomic environment of epithelial ovarian cancer that contributes to chemoresistance and to use this knowledge to identify possible targets for therapeutic intervention. The Warburg effect describes increased glucose uptake and lactate production in cancer cells. In ovarian cancer, we require a better understanding of how cancer cells reprogram their glycogen metabolism to overcome their nutrient deficient environment and become chemoresistant.
View Article and Find Full Text PDFAntiestrogen therapy (AET) is an alternative to cytotoxic chemotherapy for recurrent ovarian cancer, yet the often short duration of response suggests mechanisms of resistance. We previously demonstrated that tumor microenvironment interleukin-6/leukemia inhibitory factor (IL6/LIF) cytokines induce tumor cell JAK-STAT signaling to promote cancer growth. Crosstalk between estrogen signaling and cytokine signaling has been reported.
View Article and Find Full Text PDFMultidisciplinary in situ simulation to improve emergency obstetric care.
BMJ Simul Technol Enhanc Learn
April 2020
Urinary incontinence (UI) is common in women and is often associated with decreased quality of life. It is important to consider a range of wide differential diagnoses when evaluating a patient presenting with presumed with UI. This case describes a patient referred to urogynecology for urinary incontinence caused by a common, benign and usually asymptomatic gynecologic condition: nabothian cysts.
View Article and Find Full Text PDFArticle Synopsis
- - A 23-year-old woman presented with irregular menstrual cycles, and a pelvic ultrasound revealed ascites and irregular-looking ovaries, prompting further investigation.
- - During a diagnostic laparoscopy, doctors found "diffuse granulomatous inflammation," but the cause was initially unclear after surgery.
- - After additional tests, she was diagnosed with pelvic inflammatory disease caused by Chlamydia, highlighting that granulomatous inflammation can have rare underlying causes that should be considered in diagnosis.