Publications by Katelyn M Jones

Publications by authors named "Katelyn M Jones"

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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer.

Jinghui Liu Yue Zhao Daheng He Katelyn M Jones Shan Tang

Cell Rep Med

April 2023

Enzalutamide (ENZA), a second-generation androgen receptor antagonist, has significantly increased progression-free and overall survival of patients with metastatic prostate cancer (PCa). However, resistance remains a prominent obstacle in treatment. Utilizing a kinome-wide CRISPR-Cas9 knockout screen, we identified casein kinase 1α (CK1α) as a therapeutic target to overcome ENZA resistance.

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