Publications by authors named "Katelyn E Madigan"
Article Synopsis
- Erythropoietic protoporphyria (EPP) is a genetic disorder caused by low levels of ferrochelatase, affecting heme production, while X-linked protoporphyria (XLP) results from overactive δ-aminolevulinic acid synthase 2 (ALAS2), leading to similar symptoms.
- Both conditions cause a buildup of protoporphyrin IX, resulting in extreme sensitivity to light and possible severe liver issues in some patients.
- New treatments like dersimelagon are being developed to improve management options for EPP and XLP beyond traditional methods of sun avoidance.
Background: Intrabolus pressure (IBP) recorded by high-resolution manometry (HRM) portrays the compartmentalized force on a bolus during esophageal peristalsis. HRM may be a reliable screening tool for esophageal dysmotility in patients with elevated average maximum IBP (AM-IBP). Timed barium esophagram (TBE) is a validated measure of esophageal emptying disorders, such as esophagogastric junction outflow obstruction and achalasia.
View Article and Find Full Text PDFDistinctive Clinical Correlates of Small Intestinal Bacterial Overgrowth with Methanogens.
Clin Gastroenterol Hepatol
July 2022
Background And Aims: Most patients with small intestinal bacterial overgrowth (SIBO) produce hydrogen by fermentation of dietary carbohydrates; however, ∼30% of patients with SIBO are colonized with Archaea, anaerobic organisms that produce methane. SIBO is associated with a plethora of symptoms and conditions, but their diagnostic significance is unclear. We aimed to determine if specific symptoms and conditions are associated with methanogenic SIBO.
View Article and Find Full Text PDFFood Insecurity Is an Independent Risk Factor for Depressive Symptoms in Survivors of Digestive Cancers.
Cancer Epidemiol Biomarkers Prev
June 2021
Background: Colorectal and other digestive cancer survivors are at increased risk of depression, which can negatively affect health outcomes. Food insecurity (FI), the lack of consistent access to enough food, can also contribute to these health complications. The objective of this study was to determine the relationship between FI and depressive symptoms within this population.
View Article and Find Full Text PDFObjectives: The study goal was to concurrently evaluate agreement of a 9-point pulmonary ultrasound protocol and portable chest radiograph with chest CT for localization of pathology to the correct lung and also to specific anatomic lobes among a diverse group of intubated patients with acute respiratory failure.
Design: Prospective cohort study.
Setting: Medical, surgical, and neurologic ICUs at a 670-bed urban teaching hospital.