Publications by authors named "Katelyn Darowski"
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles for different phosphatase families.
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- ATP-binding cassette (ABC) transporters are important integral membrane proteins linked to various human diseases and pharmacology.
- Researchers used membrane yeast two-hybrid technology on Saccharomyces cerevisiae to create a comprehensive map of interactions among nonmitochondrial ABC transporters.
- The study reveals that these transporters engage with a diverse array of proteins, affecting their regulation and playing a key role in zinc homeostasis, thus providing valuable insights into their cellular functions.