[Prolonged paravertebral analgesia in therapy of chronic pain syndrome in critical lower-limb ischaemia].

Chronic pain syndrome in patients presenting with lower-limb critical ischaemia may have considerable significance in progression of the degree of limb ischaemia, and quality of life of patients appears to be largely determined by adequate analgesia. Currently, there is no 'gold standard' of therapy for chronic pain syndrome in critical lower-limb ischaemia, which makes it necessary to search for new effective and safe methods of analgesia. The purpose of this study was to evaluate efficacy and safety of paravertebral analgesia compared with epidural analgesia in therapy of chronic pain syndrome in critical lower-limb ischaemia.

[Sulodexide in treatment of chronic venous insufficiency. Results of the All-Russian multicenter programme ACVEDUCT].

Introduction: Pharmacotherapy occupies one of the leading places in comprehensive treatment of lower-limb chronic venous diseases (CVD) and their complications. At the same time, there are not so many therapeutic agents intended for treatment of CVD and possessing evidence-based efficacy. Sulodexide (registered in Russia as Vessel Due F) is a drug with a confirmed therapeutic effect in patients with a moderately severe course of chronic venous disease or its late stages.

[Results of splenorenal venous bypass grafting in patients with hepatocirrhosis].

Presented herein are the results of surgical treatment of 79 patients with intrahepatic portal hypertension who underwent splenorenal venous bypass grafting after splenectomy. The patients' age varied from 8 to 64 years, averaging 37.3 years.

[Possibility of operative treatment of geriatric patients with critical lower limb ischemia].

The experience of treating 106 patients of 70+ years shows the possibility of successful vascular reconstructive procedures with good immediate and long-term results, even in the presence of critical limb ischemia and severe comorbidity in geriatric patients, if not guided by the principle of maximum revascularization of the affected limbs, and minimally sufficient, through a wide use of atypical and small renovations. In addition, not only comprehensive assessment of the reserve and compensatory capacities of the patients is important, but also preoperative prevention of cardiac, pulmonary and other complications.

[Substantiation of an adequate scope of diagnostic methods and surgical procedures in patients with diabetic foot syndrome].

Analysed herein are the results of treating a total of 154 patients presenting with diabetes mellitus and pyo-necrotic alterations in the lower limbs. Duration of diabetes prior to the development of necrotic complications averagely amounted to 15 years, in 76 patients of the Study Group we determined the species-specific composition of the pathogens, the number of microbial bodies in 1 gram of necrotic tissues as well as the state of cellular and humoral immunity, and the complex of therapeutic measures was supplemented by cytokine therapy: Operative treatment in 78 patients of the control group consisted of various-scope necrectomies and open management of the wounds. The operative procedures in the Study Group patients included revascularizing operations, as well as secondary surgical debridement of the wounds with placing sutures.

[Endothelial function and cellular morphology and functionality inischemic limbs during drug therapy of obliterative atherosclerosis].

Unlabelled: The aim of the study was to develop a rationale for Vasaprostan monotherapy of ischemia in patients with obliterative lesions in lower limb arteries. The assessment of blood cell ultrastructure revealed deformation of erythrocytes and platelets, aggregation of platelets and platelets with red cells, evidencing severe rheological alterations and increased incidence of thrombotic events in patients with critical ischemia. Vasaprostan monotherapy was more effective then combined therapy without prostaglandin E1.

[Morphological characteristics and intracellular electrolytic composition of blood cells at surgeries on lower extremities arteries].

Morphological characteristics and trace and macroelement composition of blood cells flowing out of ischemic lower limb before, during and after reconstructive surgeries under different type of anesthesia. A total of 102 male patients aged 45 to 60 years with atherosclerotic occlusions of the arteries of the femoral-popliteal zone were included into the study. According to anesthesia type all the patients were divided into 3 groups: group 1 consisted of 34 patients operated under spinal anesthesia, 37 patients of group 2 underwent surgery under combined anesthesia (spinal anesthesia with intravenous sedation), 31 patients of group 3 - under total intravenous anesthesia with myoplegia and artificial pulmonary ventilation.