Publications by authors named "Kate Wetenhall"
Background: In a small, but potentially significant proportion of patients with a monoclonal gammopathy, patients show the existence of an intact monoclonal (M-) protein co-migrating with a free light chain (FLC) M-protein. Using traditional methods for detection of monoclonal immunoglobulins, only the intact M-protein may be detectable, and hence the FLC M-proteins may be missed.
Methods: Immunofixation electrophoresis (IFE) using two different sets of antisera were compared (one detecting both free and bound FLC epitopes, and one detecting only the free FLC epitopes), alongside urine protein electrophoresis and the Freelite assay in order to ascertain the best methods of detecting both types of M-proteins in this subset of patients.
Article Synopsis
- The study investigates the biochemical pathways leading to mitotic catastrophe by using a new compound, S23906, which targets DNA and disrupts its structure.
- S23906, like other known genotoxic agents, activates specific cellular responses such as gamma-H2AX and checkpoint kinase 1, highlighting its ability to induce DNA damage.
- The research finds that mitotic catastrophe occurs in a significant portion of cells after S23906 treatment, suggesting this response may be a common outcome for various forms of DNA damage.