Publications by authors named "Kate Rewers"
Article Synopsis
- - The study aimed to explore how common late-onset giant cell arteritis (GCA) is within the first year for patients newly diagnosed with polymyalgia rheumatica (PMR).
- - Researchers used advanced imaging techniques like vascular ultrasonography and FDG-PET/CT scans to monitor PMR patients and confirm findings over a year, leading to the identification of GCA.
- - Results showed a low incidence of late-onset GCA (32 per 1000 person-years) among PMR patients, indicating that subclinical GCA is also rare in the PMR population.
Purpose: In routine care, clinicians may employ 2-[18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) computed tomography (CT) to validate their initial clinical diagnosis of polymyalgia rheumatica (PMR). Nevertheless, the diagnostic utility of combining FDG-PET/CT findings with clinical presentation has not been explored. Therefore, this study aimed to investigate whether the diagnostic accuracy for PMR could be enhanced by combining FDG-PET/CT findings with the clinical baseline diagnosis or the 2012 ACR/EULAR clinical classification criteria for PMR.
View Article and Find Full Text PDFThe effect of prednisolone and a short-term prednisolone discontinuation for the diagnostic accuracy of FDG-PET/CT in polymyalgia rheumatica-a prospective study of 101 patients.
Eur J Nucl Med Mol Imaging
July 2024
Purpose: 2-[18F]Fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) has been suggested as an imaging modality to diagnose polymyalgia rheumatica (PMR). However, the applicability of FDG-PET/CT remains unclear, especially following glucocorticoid administration. This study aimed to investigate the diagnostic accuracy of FDG-PET/CT before and during prednisolone treatment, as well as following short-term prednisolone discontinuation.
View Article and Find Full Text PDFArticle Synopsis
- EBV-associated T-cell and NK-cell lymphoproliferative diseases are rare and deadly, especially in Caucasians, with this study focusing on a 19-year-old boy diagnosed with systemic EBV positive T-cell lymphoma.
- The research highlights severe immune issues, including lympho-depletion and halted thymopoiesis, linked to heightened EBV and immune activation.
- A significant somatic missense variant in the proto-oncogene FYN was found, with a 48% variant allele frequency in this case, suggesting it may play a role in excessive T-cell activation and could be a potential target for future treatments.
Purpose: The preferred nuclear medicine method for identification of hyperfunctioning parathyroid glands in hyperparathyroidism (HPT) develops continuously in relation to the technological progress. Diagnostic methods based on PET/CT have during recent years evolved with new tracer possibilities competing with traditional scintigraphic methods. This investigation is a head-to-head comparison of Tc-99m-sestamibi SPECT/CT gamma camera scintigraphy (sestamibi SPECT/CT) and C-11-L-methionin PET/CT imaging (methionine PET/CT) for preoperative identification of hyperfunctioning parathyroid glands.
View Article and Find Full Text PDFPurpose: The purpose of the study was to define reference ranges for quantitative parameters in [(99m)Tc]mercaptoacetyltriglycerine ([(99m)Tc]MAG3) renography to assist interpretation in a semi-automated (Xeleris, GE) compared to a manual (Picker, Odyssey) software package.
Procedures: Forty-eight subjects approved for renal donation were evaluated with [(99m)Tc]MAG3 renography using both the Xeleris and the Picker software.
Results: Reference ranges for the two software were comparable regarding the relative function of the two kidneys (the split function, SF) and the residual activities (RA).