Mifepristone and rapamycin have non-additive benefits for life span in mated female .

The drugs mifepristone and rapamycin were compared for their relative ability to increase the life span of mated female . Titration of rapamycin indicated an optimal concentration of approximately 50 μM, which increased median life span here by average +81%. Meta-analysis of previous mifepristone titrations indicated an optimal concentration of approximately 466 μM, which increased median life span here by average +114%.