Publications by authors named "Kate N O Neill"
Health care utilization and the associated costs attributable to cardiovascular disease in Ireland: a cross-sectional study.
Eur Heart J Qual Care Clin Outcomes
February 2024
Background: Cardiovascular disease (CVD) is the leading cause of mortality and disability globally. We examined healthcare service utilization and costs attributable to CVD in Ireland in the period before the introduction of a major healthcare reform in 2016.
Methods: Secondary analysis of data from 8 113 participants of the first wave of The Irish Longitudinal Study on Ageing.
Background: Socioeconomic inequalities in cardiovascular disease risk begin early in life and are more pronounced in females than males later in life. Causal atherogenic traits explaining this are not well understood. We explored sex-specific associations between childhood socioeconomic position (SEP) and molecular measures of systemic metabolism across early life.
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- Mitochondrial DNA haplogroups (H, U, J, T, K, V, W, I, and X) were studied for their relationship with cardiometabolic risk factors in a cohort from birth to age 18, focusing on sex differences.
- Data from 7,954 participants revealed that most haplogroups showed no significant association with cardiometabolic factors, except for slight variations observed in haplogroups V and X in females and haplogroup I in males during specific age points.
- Overall, the findings suggest minimal evidence supporting a link between mitochondrial DNA haplogroups and cardiometabolic risk factors, indicating that other factors may play a more significant role in risk development.
Article Synopsis
- The study aimed to model the growth patterns of children from pregnancy through the first five years using complex statistical models called linear spline multilevel models.
- Conducted in a maternity hospital in Dublin, it involved 720-759 mother-child pairs from the ROLO study, which originally focused on the effects of a low glycaemic index diet in preventing large birth weights.
- The findings revealed that growth rates were highest during pregnancy and immediately after birth, with a gradual slowdown in growth as children matured, demonstrating the effectiveness of the chosen modeling approach for tracking growth over time.
Objective: To examine the association between maternal metabolic parameters in pregnancy and growth trajectories up to 5 years of age.
Methods: Data from mother-child pairs who participated in the ROLO study, a randomized trial examining the impact of a low glycaemic index diet on the recurrence of macrosomia, were analysed. Fetal and child growth trajectories were developed from longitudinal measurements from 20 weeks gestation up to 5 years of age.
Background: Sex differences in systolic blood pressure (SBP) emerge during adolescence but the role of puberty is not well understood. We examined sex-specific changes in SBP preceding and following puberty and examined the impact of puberty timing on SBP trajectories in females and males.
Methods: Trajectories of SBP before and after puberty and by timing of puberty in females and males in a contemporary birth cohort study were analyzed.
Background: Sex differences in cardiometabolic disease risk are commonly observed across the life course but are poorly understood and may be due to different associations of adiposity with cardiometabolic risk in females and males. We examined whether adiposity is differently associated with cardiometabolic trait levels in females and males at 3 different life stages.
Methods And Findings: Data were from 2 generations (offspring, Generation 1 [G1] born in 1991/1992 and their parents, Generation 0 [G0]) of a United Kingdom population-based birth cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC).
Objectives: To explore trends in pharmaceutical expenditure on diabetes between 2011 and 2015, describing trends in expenditure on blood glucose-lowering medications and estimating the effect of cost-containment measures implemented during this time.
Design: Repeated cross-sectional study of national pharmacy claims data in Ireland.
Participants: Patients' dispensed items used in the treatment or management of diabetes.
Purpose: We simulate population shifts in the distribution of sugar-sweetened beverage (SSB) consumption and address previous methodological limitations to provide valid and reliable estimates of the potential impact of public health interventions on type II diabetes incidence in Ireland.
Methods: A comparative risk assessment was conducted, using distribution shift calculations to estimate potential impact fractions (PIFs) for percentage reductions in SSB consumption. Data from the Survey of Lifestyle, Attitudes and Nutrition was analyzed.
Introduction: With the rising prevalence of severe obesity and type 2 diabetes (T2D), bariatric surgery offers a clinical and cost-effective treatment for carefully selected patients. Despite this, the provision of surgical services varies significantly between countries.
Objective: To inform health service planning by estimating the number of people who would potentially benefit from bariatric surgery.