The role of the dopamine D1 receptor in anticipatory pleasure and social play.

Social play is a highly rewarding activity seen across mammalian species that is vital for neurobehavioural development. Dysfunctions in social play are seen across psychiatric and neurodevelopmental disorders positing the importance of understanding the neurobiological mechanisms underlying social play. A multitude of neurotransmitter systems have been implicated in social play, with the present study focused on the role of dopamine, specifically the dopamine D1 receptor.

Dopamine D1 receptor and effort-based decision making in rats: The moderating effect of sex.

Dopamine is a modulating factor in effort-based decision-making, and emerging evidence from pharmacological research suggests that the dopamine D1 receptor is the primary regulator. Given the limited selectivity of pharmacological tools, we further explored this hypothesis using dopamine D1 mutant (DAD1) rats which have a specific genetic reduction in functional D1 receptors. Moreover, given the strong focus on males in neuroscience research in general and in the role of D1 receptors in effort-based learning, we compared both sexes in the present study.

Choices about whether to wait: Changes in delay discounting without changes in time perception.

Delay discounting occurs when the present, subjective value of a reward decreases as a function of delay. Delay discounting is steeper when individuals must wait during the delay, and delay discounting rates for decisions about waiting are not strongly correlated with those for decisions about postponing without waiting. We examined whether changes in delay discounting in choices about waiting are linked to changes in subjective time perception.