Publications by authors named "Kate Devine"
Objective: To study cycle outcomes of women who choose to pursue oocyte cryopreservation, using published age-specific oocyte recommendations.
Design: Retrospective cohort.
Setting: Clinic.
Objective: To evaluate the predictive value of sperm morphology, specifically teratospermia, seen during initial semen analysis on the success of intrauterine insemination (IUI) cycles and pregnancy outcomes.
Methods: A retrospective cohort analysis on patients undergoing IUI at a large US fertility network. Baseline demographic characteristics, primary infertility diagnoses, and pregnancy outcomes were recorded.
Article Synopsis
- The study looked at why people in the U.S. choose to donate embryos they don’t use after IVF treatment.
- A survey was sent to people interested in donating embryos, and 337 people shared their decisions: 230 donated, 75 tossed them, and 25 were unsure.
- The choice to donate was influenced by personal beliefs, concerns for future kids, and feelings about embryos, with those who donated feeling happier with their decision than those who discarded them.
Objective: To evaluate differences in reproductive and neonatal outcomes on the basis of the time interval from cesarean delivery to subsequent frozen embryo transfer (FET).
Design: Retrospective cohort.
Setting: Multicenter fertility practice.
Article Synopsis
- Scientists wanted to know if higher estradiol levels (a hormone) on the day of embryo transfer (ET) helped to have better pregnancy outcomes (like healthy babies).
- They looked at a lot of fresh ET cycles from different clinics and excluded patients with specific issues, finding that out of over 17,000 cycles, about 29% resulted in good pregnancy outcomes.
- The study showed that higher estradiol levels can lead to better outcomes, but after reaching 2000-2999 pg/mL, the benefits stopped increasing, meaning they stayed about the same for even higher levels.
Objective: To study the primary objective of clinical pregnancy (CP) rate per ovarian stimulation with intrauterine insemination (OS-IUI) treatment cycle in patients with repetitive cycles up to a maximum of 8 cycles.
Design: Retrospective cohort.
Setting: Large fertility clinic.
Objective: To study the relationship between high antimüllerian hormone (AMH) levels in oocyte donors and embryo development and pregnancy outcomes among donor oocyte recipients.
Design: Retrospective cohort study.
Setting: Donor Egg Bank Database.
Purpose: Assess the rate, rationale, and characteristics of patients who cryopreserved and subsequently discarded their oocytes, and compare their characteristics to patients with continued cryopreservation of oocytes.
Methods: All patients who disposed of cryopreserved oocytes between 2009 and 2022 reported their reason for discarding their oocytes. This was a retrospective cohort study.
Objective: To evaluate the cost-effectiveness of in vitro fertilization with preimplantation genetic testing for monogenic disease (IVF + PGT-M) in the conception of a nonsickle cell disease (non-SCD) individual compared with standard of care treatment for a naturally conceived, sickle cell disease (SCD)-affected individual.
Design: A Markov simulation model was constructed to evaluate a one-time IVF + PGT-M treatment compared with the lifetime standard of care costs of treatment for an individual potentially born with SCD. Using an annual discount rate of 3% for cost and outcome measures, quality-adjusted life years were constructed from utility weights and life expectancy values and then used as the effectiveness measurement.
The field of reproductive endocrinology and infertility (REI) is at a crossroads; there is a mismatch between demand for reproductive endocrinology, infertility and assisted reproductive technology (ART) services, and availability of care. This document's focus is to provide data justifying the critical need for increased provision of fertility services in the United States now and into the future, offer approaches to rectify the developing physician shortage problem, and suggest a framework for the discussion on how to meet that increase in demand. The Society of REI recommend the following: 1.
View Article and Find Full Text PDFThe technique and platform used for preimplantation genetic testing for aneuploidy (PGT-A) have undergone significant changes over time. The contemporary technique utilizes trophectoderm biopsy followed by next-generation sequencing (NGS). The goal of this study was to explore the role of PGT-A using NGS technique exclusively in contemporary fertilization (IVF) practice.
View Article and Find Full Text PDFImportance: To date, recurrent implantation failure (RIF) has no clear definition and no clearly identified impaired function. Hence, the term RIF is currently used somewhat haphazardly, on the basis of clinicians' judgment.
Objective: International experts in reproductive medicine met on July 1, 2022, in Lugano, Switzerland, to review the different facets of RIF and define the diagnosis and its appropriate management.
Objective: To identify whether the serum estradiol (E2) level on the day of human chorionic gonadotropin (hCG) trigger or luteinizing hormone (LH) surge (hCG-LH) was associated with the live birth rate (LBR) during ovulation induction (OI) or controlled ovarian hyperstimulation with letrozole followed by intrauterine insemination (IUI).
Design: Retrospective cohort study.
Setting: Large, multicenter private practice.
Importance: Endometrial receptivity testing is purported to improve live birth following frozen embryo transfer by identifying the optimal embryo transfer time for an individual patient; however, data are conflicting.
Objective: To compare live birth from single euploid frozen embryo transfer according to endometrial receptivity testing vs standardized timing.
Design, Setting, And Participants: Double-blind, randomized clinical trial at 30 sites within a multicenter private fertility practice in the Eastern US.
Objective: To evaluate potential variation in the euploid blastocyst rate and live birth rate (LBR) per single frozen euploid blastocyst transfer, among 4 unique United States reproductive genetics laboratories. Analyses were limited to blastocysts derived from vitrified donor oocytes, to minimize variation in oocyte quality.
Design: Retrospective cohort study from 2016 to 2020.
Granulosa cells (GCs) must respond appropriately to follicle-stimulating hormone (FSH) for proper follicle maturation. FSH activates protein kinase A (PKA) leading to phosphorylation of the cyclic AMP response element binding protein-1 (CREB1). We identified a unique A-kinase anchoring protein (AKAP13) containing a Rho guanine nucleotide exchange factor (RhoGEF) region that was induced in GCs during folliculogenesis.
View Article and Find Full Text PDFThe high efficacy of modern assisted reproductive technology (ART) and increase in the number of noninfertile patients who are using ART for family building in the United States call into question the relevance of the standard, one-size-fits-all infertility evaluation. Here, we explore whether all patients presenting for ART need uterine cavity and tubal assessment and what tests are most appropriate, efficient, and cost-effective in current times.
View Article and Find Full Text PDFObjective: To determine whether endometrial receptivity analysis (ERA) improves live births in patients with and without a history of unsuccessful frozen embryo transfers (FETs).
Design: Retrospective cohort study.
Setting: Large reproductive center.