Publications by authors named "Kate Colette Tatham"
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.
Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.
Design, Setting, And Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin.
Rationale: Primary graft dysfunction in lung transplant recipients derives from the initial, largely leukocyte-dependent, ischaemia-reperfusion injury. Intravascular lung-marginated monocytes have been shown to play key roles in experimental acute lung injury, but their contribution to lung ischaemia-reperfusion injury post transplantation is unknown.
Objective: To define the role of donor intravascular monocytes in lung transplant-related acute lung injury and primary graft dysfunction.
Article Synopsis
- Lung transplantation can help patients with severe lung disease, but faces challenges like a lack of donors, lung inflammation, and injury during surgery.
- Ex vivo lung perfusion is a new method being tested in clinical trials to improve lung transplantation outcomes by overcoming these issues.
- This research focuses on understanding the cellular and molecular processes involved in primary graft dysfunction, specifically looking at how pulmonary inflammation affects lung transplants using a specialized lung model.