Antimicrobial Susceptibility Patterns Among Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in a Large Pediatric Hospital in the United Kingdom.

Of the 551 extended spectrum β-lactamase-producing isolates characterized, the MIC90 for Escherichia coli, Klebsiella spp., and Enterobacter spp. were in the susceptible range when tested against meropenem, but were in the resistant range for all other antimicrobials tested excluding E coli and Klebsiella spp.

The use of tissue sealants to deliver antibiotics to an orthopaedic surgical site with a titanium implant.

Background: Orthopaedic surgery is associated with unacceptable infection rates that respond poorly to systemic antibiotics. The objective of this study was to use an animal model for orthopaedic implant infection to examine the ability of a new-generation fibrin tissue sealant to effectively deliver antibiotics to the surgical site.

Methods: The antibiotics cefazolin, fusidic acid or 5-fluorouracil were blended into Vitagel tissue sealant.