3,4-Dihalo-5-hydroxy-2(5)-furanones: Highly Reactive Small Molecules.

3,4-Dichloro-5-hydroxy-2(5)-furanone and its dibromo analog are highly reactive molecules. Both are members of the 2(5)-furanone family, which are important as pharmacophores present in drugs and natural products. Compounds possessing the 2(5)-furanone skeleton isolated from plants and marine organisms exhibit bioactivity against various microorganisms and viruses and can also be used in other medical treatments.

Glycoconjugates of Mucochloric Acid-Synthesis and Biological Activity.

The pharmacological effects of the presence of a sugar moiety, 1,2,3-triazole ring and silyl groups in the structure of biologically active compounds have been extensively studied in drug design and medicinal chemistry. These components can be useful tools to tailoring the bioavailability of target molecules. Herein we present the study on the impact of the sugar substituent structure and triisopropylsilyl group presence on the anticancer activity of mucochloric acid (MCA) derivatives containing the furan-2(5)-one or 2-pyrrol-2-one core.

Synthesis and Preliminary Anticancer Activity Assessment of N-Glycosides of 2-Amino-1,3,4-thiadiazoles.

The addition of 2-amino-1,3,4-thiadiazole derivatives with parallel iodination of differently protected glycals has been achieved using a double molar excess of molecular iodine under mild conditions. The corresponding thiadiazole derivatives of N-glycosides were obtained in good yields and anomeric selectivity. The usage of iodine as a catalyst makes this method easy, inexpensive, and successfully useable in reactions with sugars.