Glycoprotein A (GARP) in children who outgrow food allergy.

Background: There is little understanding of the mechanisms by which food allergy (FA) develops into persistent disease, or by which symptoms it regresses. Food allergy is a major health problem in developed countries, where the prevalence reaches up to 6% in children and 3% in the adult population.

Objective: Children with food allergy remission (FAR) and those without FAR below five years of age, were compared 7-10 years with respect to clinical data and expression of glycoprotein A repetitions predominant (GARP) on peripheral blood mononuclear cells.

A 2-year-old girl with chronic crackles after respiratory syncytial virus infection: a case report.

Background: Respiratory syncytial virus is the most common cause of lower respiratory tract infections in infants and young children. While the majority of infants display only mild upper respiratory tract infection or occasionally otitis media, around one-third will develop an infection of the lower respiratory tract, usually bronchiolitis. There is now convincing evidence from a number of cohorts that respiratory syncytial virus is a significant, independent risk factor for later wheezing, at least within the first decade of life.

Quality of life in asthmatic children and their caregivers after two-year treatment with omalizumab, a real-life study.

Introduction: Omalizumab, a monoclonal anti-immunoglobulin E antibody, has been successfully used as a supplementary therapy to improve asthma control in children aged ≥ 6 years with severe persistent allergic asthma.

Aim: To demonstrate the quality of life in children with severe asthma and their caregivers, and changes from baseline in forced expiratory volume in 1 s (FEV) and daily inhaled corticosteroids (ICS) dose after 2-year treatment with omalizumab.

Material And Methods: Participants were seen in the clinic at enrollment (visit 1), after 16 weeks (visit 2), after 52 weeks (visit 3) and after 104 weeks (visit 4) of treatment with omalizumab.

Clinical and immunological effects of vitamin D supplementation during the pollen season in children with allergic rhinitis.

Introduction: Vitamin D deficiency has been proposed as a potential contributing factor in patients with allergic diseases. We compared the clinical and immunological effects of vitamin D supplementation to placebo during the pollen season in children with allergic rhinitis.

Material And Methods: Thirty-eight children aged 5-12, sensitive to grass pollen, participated in a prospective, randomized, double-blind, placebo-controlled trial.

Effect of Lactobacillus rhamnosus GG and vitamin D supplementation on the immunologic effectiveness of grass-specific sublingual immunotherapy in children with allergy.

Background: An important issue in sublingual immunotherapy (SLIT) is how to improve efficacy.

Objective: To compare the clinical and immunologic efficacy of SLIT given alone and, to enhance clinical efficacy, given with probiotic or vitamin D supplementation.

Methods: One hundred children, ages 5-12 years, sensitive to grass pollen, with allergic rhinitis participated in a 5-month prospective, randomized, double-blind, placebo-controlled trial.

Food allergy is associated with recurrent respiratory tract infections during childhood.

Introduction: To find out whether children with food allergy have an increased risk of recurrent upper and lower respiratory tract infections and of asthma.

Aim: To describe the clinical profile of children diagnosed with food allergy referred to the Allergy Clinic.

Material And Methods: We conducted a retrospective study to assess the patients' demographic, anthropometric and clinical data.

Methacholine challenge testing is superior to the exercise challenge for detecting asthma in children.

Background: Exercise-induced bronchoconstriction occurs in a large proportion of children with asthma.

Objective: To compare the predictive value of methacholine challenge testing (MCCT) and the exercise treadmill challenge (ETC) for detecting asthma in children with postexercise symptoms.

Methods: This was a prospective study of children 10 to 18 years old with postexercise symptoms.

Total specific airway resistance vs spirometry in asthma evaluation in children in a large real-life population.

Background: Total specific airway resistance (sRtot) has been introduced as an alternative technique to assess lung function with a particular application to younger children with asthma.

Objective: To establish a diagnostic value of the body plethysmographic parameter (sRtot) in asthma diagnosis in young children.

Methods: This was a prospective, noninterventional study.

Omalizumab in the prevention of anaphylaxis during immunotherapy: a case report.

Omalizumab is approved for the treatment of chronic severe persistent asthma. As a trigger for anaphylaxis, the frequency of subcutaneous specific immunotherapy (SCIT) is high. We report the case of a 11-year-old boy with severe allergic asthma.

Omalizumab as a new therapeutic approach for children with severe asthma.

Omalizumab has been shown to improve asthma control when added to a regimen of guideline-based therapy for inner-city children and adolescents, nearly eliminating seasonal peaks in exacerbation and reducing the need for other medications to control asthma. Below, we describe a case of a 17-year-old non-smoker with a history of severe asthma admitted to our clinic after unsuccessful 10-year immunotherapy. The patient fulfilled the criteria for anti-IgE therapy, he was prescribed omalizumab 600 mg every 2 weeks.