Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in induced sputum from farmers with and without COPD.

The cathelicidin LL-37 is an antimicrobial and lipopolysaccharide neutralizing peptide, possessing pro-inflammatory, tissue repair and remodeling activities. Recent reports indicate that the progression of COPD might be connected with increased levels of LL-37. The numerous experimental data show the potential role of LL-37 in the response to the exposure to organic dust (containing lipopolysaccharide and microorganisms) which is one of the major COPD causative factors.

Effect of nimesulide-a preferential COX-2 inhibitor on arterial blood pressure, compared to ketoprofen.

Clinical and experimental studies have shown that renal and cardiovascular effects of most selective COX-2 inhibitors (rofecoxib, celecoxib) are similar to other traditional NSAIDs (dual COX inhibitors). In these study the effect of nimesulide--preferential COX-2 inhibitor, administration on 24-hour blood pressure profile was investigated in 40 adult individuals on antihypertensive therapy with pain states caused by osteoartritis. Nimesulide was administered orally, twice a day at the conventional dose of 0.