Amantadine in Treatment of Dysthymia-The Pilot Case Series Study.

Dysthymia is a common chronic mood disorder in which isolated symptoms of depression persist for at least 2 years. Despite the many medications recommended for the treatment of dysthymia, no recommendations have yet been made for the treatment of patients who fail to achieve clinical improvement. This justifies attempts to identify second-line drugs for the treatment of dysthymia.

Amantadine in the Treatment of Sexual Inactivity in Schizophrenia Patients Taking Atypical Antipsychotics-The Pilot Case Series Study.

Sexual dysfunctions in people with schizophrenia are more severe than in the general population and are an important element in the treatment of schizophrenia. The mechanism of sexual dysfunction in patients treated for schizophrenia may be related to the side effects of antipsychotic drugs (hyperprolactinemia, suppression of the reward system), but it may also be related to the pathogenesis of schizophrenia itself. The aim of the study was to present the possibility of using amantadine in the treatment of sexual dysfunction in schizophrenia without the concomitant hyperprolactinemia.

Multidimensional Sexual Well-being Scale for Older Adults: Validity Evidence from a Polish Sample.

Here, we report the results of a Polish adaptation of the Multidimensional Sexual Well-being Scale (MSWBS) for older adults. The MSWBS is a short self-report scale for assessing the five dimensions of an individual's sexual well-being: frequency of caressing, sexual intimacy, sexual compliance, sexual satisfaction, and sexual distress. The aim of our adaptation was to examine the utility of the scale in a country with conservative views on the sexuality of older people, which will help health care providers and researchers to better understand the sexual needs of older people.

Perceived Decrease in Workplace Security Since the Beginning of the COVID-19 Pandemic: The Importance of Management Styles and Work-Related Attitudes.

The coronavirus disease 2019 (COVID-19) pandemic has reduced the sense of security of people in everyday life. The efforts of managers in the workplace to minimize the health risks and economic damage, however, can provide the employees with a greater sense of security. The aim of this study was to identify the types of workplace responses to the pandemic outbreak with respect to the characteristics of employees and their employers accomplishing the differences in subjective sense of workplace security before the pandemic and during the outbreak.

Digital or In-Person: The Relationship Between Mode of Interpersonal Communication During the COVID-19 Pandemic and Mental Health in Older Adults From 27 Countries.

Social distancing has limited the spread of the coronavirus (COVID-19), but also changed communication patterns. However, studies of how mental health in older adults relates to the usage of different modes of interpersonal communication are sparse. The aim of this study was to analyze how COVID-19-related changes in the frequencies of using different modes of communication (digital or in-person) have influenced mental health in older adults from 27 countries.

Enhancement in Phospholipase D Activity as a New Proposed Molecular Mechanism of Haloperidol-Induced Neurotoxicity.

Membrane phospholipase D (PLD) is associated with numerous neuronal functions, such as axonal growth, synaptogenesis, formation of secretory vesicles, neurodegeneration, and apoptosis. PLD acts mainly on phosphatidylcholine, from which phosphatidic acid (PA) and choline are formed. In turn, PA is a key element of the PLD-dependent secondary messenger system.

The Effect of Smartphone-Based Cognitive Training on the Functional/Cognitive Markers of Schizophrenia: A One-Year Randomized Study.

Background: Cognitive impairment is associated with long-term disability that results in the deterioration of both the social and professional status of individuals with schizophrenia. The impact of antipsychotic therapy on cognitive function is insufficient. Cognitive training is therefore proposed as a tool for cognitive rehabilitation in schizophrenia.

"No matter how old I am, I don't like what my stomach looks like." Lifespan perspective on the changes in self-assessment of attractiveness and life satisfaction in women.

The study aimed to examine the association between self-assessment of attractiveness and life satisfaction in women, where age was a potential moderator of this relationship. A cross-sectional study of 360 women aged 18 to 89 was performed. Participants assessed their overall attractiveness, the attractiveness of their individual body parts, and their life satisfaction.

Sexual activity and life satisfaction in older adults.

Aim: Based on the concept of successful ageing and research reports on the benefits of maintaining sexual activity in mid- to late life, the purpose of the current study was to examine the relationship between global life satisfaction and sexual satisfaction in adults older than 60 years. The study also analyzed the relationship between various forms of sexual activity (genital and non-genital) and both types of satisfaction.

Methods: Thirty-three men and 50 women (N =83) were interviewed by using two structuralized questionnaires.

A telemedicine platform to improve clinical parameters in paranoid schizophrenia patients: Results of a one-year randomized study.

Objective: The study objective was to test a smartphone-based MONEO platform designed to improve the clinical condition of paranoid schizophrenia patients. Telemedicine treatment is considered to be as effective as traditional treatment in outpatient clinics.

Method: A total of 290 patients with paranoid schizophrenia in the symptomatic remission state were recruited to this 12-month multicenter, open-label randomized trial.

Treatment Compliance in the Long-Term Paranoid Schizophrenia Telemedicine Study.

Schizophrenia is a chronic disease with a relatively high relapse rate. Different methods are introduced to improve compliance of the patients treated by psychiatrists; among them, a new and promising attitude is telepsychiatry. The 12-month clinical study of the compliance in paranoid schizophrenia was performed on the group of 199 patients.

Impact of olanzapine on cognitive functions in patients with schizophrenia during an observation period of six months.

Objective: The objective of our study was to evaluate the effect of olanzapine treatment on selected cognitive functions in patients suffering from schizophrenia during an observation period of six-months.

Subjects And Methods: Twenty patients with a diagnosis of schizophrenia according to ICD-10 criteria for research were examined. One day before initiation of olanzapine a baseline assessment was performed.