Irisin plasma concentration in PCOS and healthy subjects is related to body fat content and android fat distribution.

Irisin (Ir), a recently identified adipo-myokine, cleaved and secreted from the protein FNDC5 in response to physical activity, has been postulated to induce the differentiation of a subset of white adipocytes into brown fat and to mediate the beneficial effects on metabolic homeostasis. Metabolic syndrome (MS), a cluster of factors leading to impaired energy homeostasis, affects a significant proportion of subjects suffering from polycystic ovary syndrome (PCOS). The aim of our study was to investigate the relationship between Ir plasma concentrations and metabolic disturbances.

[Irisin--a new mediator of energy homeostasis].

Skeletal muscles as an active hormonal compartment in the response of physical activity secrete substances named myokines capable of modulating metabolic processes. Myokines take part in communication between muscles and other tissues. Irisin (Ir) - a newly discovered adipomyokine - is cleaved and secreted to the circulation from a fibronectin type III domain containing protein 5 (FNDC5).

L-thyroxine therapy and growth processes in children with Down syndrome.

Background: Subclinical hypothyroidism is more frequent in newborns with DS (Down syndrome) than in the population of healthy children. The lack of appropriate treatment can deepen the children's retardation as well as affecting the process of their growth.

Objectives: Evaluation of the impact of hypothyroidism substitution treatment on the process of growth and physical development in children with DS.