Publications by authors named "Katarzyna Olejnik"
Tight Junctions and Cancer: Targeting Claudin-1 and Claudin-4 in Thyroid Pathologies.
Pharmaceuticals (Basel)
September 2024
Article Synopsis
- Claudins, specifically claudin-1 and claudin-4, are tight junction proteins involved in the progression of thyroid cancers and are potential therapeutic targets.
- The study analyzed 162 thyroid samples from patients with various pathologies, finding distinct expression patterns: goiters had negative claudin-1 and mostly positive claudin-4, while papillary thyroid cancers and adenomas showed positive claudin-1 and claudin-4.
- High expression levels of claudin-1 were linked to poorer overall survival rates in patients, highlighting its role as a prognostic factor and indicating a need for further trials to explore claudin targeting in clinical settings.
Background: SARS-CoV-2 can damage human placentas, leading to pregnancy complications, such as preeclampsia and premature birth. This study investigates the histopathological changes found in COVID-19-affected placentas.
Materials And Methods: This study included 23 placentas from patients with active COVID-19 during delivery and 22 samples from patients without COVID-19 infection in their medical history.