Publications by authors named "Katarzyna M Groborz"
Activated effector caspases 3, 6 and 7 are responsible for cleaving a number of target substrates, leading to the ultimate destruction of cells apoptosis. The functions of caspases 3 and 7 in apoptosis execution have been widely studied over the years with multiple chemical probes for both of these enzymes. In contrast, caspase 6 seems to be largely neglected when compared to the heavily studied caspases 3 and 7.
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- Researchers created targeted probes to detect enzymes, specifically focusing on proteases using activity-based probes labeled with identifiable tags like fluorophores.
- Due to issues with spectral overlap of fluorophores, they developed new lanthanide-labeled probes suitable for mass cytometry, allowing for the simultaneous monitoring of multiple proteases.
- This method enabled the identification of four different proteases in various cell lines and blood samples, establishing a new approach for analyzing enzyme activity in multiplex form.