Identification of a new genetic variant (G231N, E232T, N235D) of peptidylarginine deiminase from in advanced periodontitis.

Chronic periodontitis (CP), an inflammatory disease of periodontal tissues driven by a dysbiotic subgingival bacterial biofilm, is also associated with several systemic diseases, including rheumatoid arthritis (RA). , one of the bacterial species implicated in CP as a keystone pathogen produces peptidyl arginine deiminase (PPAD) that citrullinates C-terminal arginine residues in proteins and peptides. Autoimmunity to citrullinated epitopes is crucial in RA, hence PPAD activity is considered a possible mechanistic link between CP and RA.

Host and bacterial factors linking periodontitis and rheumatoid arthritis.

Observations from numerous clinical, epidemiological and serological studies link periodontitis with severity and progression of rheumatoid arthritis. The strong association is observed despite totally different aetiology of these two diseases, periodontitis being driven by dysbiotic microbial flora on the tooth surface below the gum line, while rheumatoid arthritis being the autoimmune disease powered by anti-citrullinated protein antibodies (ACPAs). Here we discuss genetic and environmental risk factors underlying development of both diseases with special emphasis on bacteria implicated in pathogenicity of periodontitis.

Clinics and genetic background of hereditary gingival fibromatosis.

Background: Hereditary gingival fibromatosis (HGF) is a rare condition characterized by slowly progressive overgrowth of the gingiva. The severity of overgrowth may differ from mild causing phonetic and masticatory issues, to severe resulting in diastemas or malposition of teeth. Both, autosomal-dominant and autosomal-recessive forms of HGF are described.

Shields the Periodontal Killer from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival Tissue.

is a pathogenic fungus capable of switching its morphology between yeast-like cells and filamentous hyphae and can associate with bacteria to form mixed biofilms resistant to antibiotics. In these structures, the fungal milieu can play a protective function for bacteria as has recently been reported for and a periodontal pathogen-. Our current study aimed to determine how this type of mutual microbe protection within the mixed biofilm affects the contacting host cells.

Metabolomic Status of The Oral Cavity in Chronic Periodontitis.

Unlabelled: Chronic periodontitis is an inflammatory disease of tooth-supporting tissues associated with Porphyromonas gingivalis. Expansion and invasion of this bacterium into the periodontium is associated with changes in the metabolome of the oral cavity.

Materials And Methods: Metabolomics analysis of mouth washout and tongue swab samples based on proton nuclear magnetic resonance (H-NMR) method was employed to determine metabolic status of the oral cavity in chronic periodontal disease.

Fibroblasts from recurrent fibrotic overgrowths reveal high rate of proliferation in vitro - findings from the study of hereditary and idiopathic gingival fibromatosis.

Purpose: Investigate the content of fibrotic fibrils in gingival tissue and the proliferation of fibroblasts collected from recurrent and non-recurrent hereditary gingival fibromatosis (HGF) and idiopathic gingival fibromatosis (IGF).

Methods: Gingival biopsies were collected from HGF (n = 3) and IGF (n = 3) donors with recurrent and non-recurrent gingival overgrowths and from a control group (Ctrl, n = 3). Hematoxylin staining was performed to evaluate the histomorphology of gingival tissue.

TIMP-1 association with collagen type I overproduction in hereditary gingival fibromatosis.

Objectives: To investigate the processes associated with the excessive production of collagen I in hereditary gingival fibromatosis (HGF).

Materials And Methods: Three HGF subjects and five controls were enrolled in the study. Histomorphological and immunohistological analyses were performed on gingival tissues.

Association of Distinct Fine Specificities of Anti-Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis.

Objective: In addition to the long-established link with smoking, periodontitis (PD) is a risk factor for rheumatoid arthritis (RA). This study was undertaken to elucidate the mechanism by which PD could induce antibodies to citrullinated peptides (ACPAs), by examining the antibody response to a novel citrullinated peptide of cytokeratin 13 (CK-13) identified in gingival crevicular fluid (GCF), and comparing the response to 4 other citrullinated peptides in patients with RA who were well-characterized for PD and smoking.

Methods: The citrullinomes of GCF and periodontal tissue from patients with PD were mapped by mass spectrometry.

Gingival Fibromatosis with Significant De Novo Formation of Fibrotic Tissue and a High Rate of Recurrence.

BACKGROUND Hereditary gingival fibromatosis is characterized by slowly progressive enlargement of the gingiva that can present as an isolated condition or present as part of various syndromes. CASE REPORT An 11-year-old female reported with a gingival lesion that caused masticatory problems and poor oral hygiene. Periodontal examination revealed a dense tissue covering 30% of her teeth crowns within both jaws.

[Unilateral idiopathic gingival fibromatosis--a case report].

Gingival fibromatosis is a painless gingival overgrowth. It may result in difficulties with proper dental hygiene keeping, mastication and occlusion. Herein, a case of a 10-year-old patient was described.

Gingival fibromatosis: clinical, molecular and therapeutic issues.

Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as slowly progressive, local or diffuse enlargements within marginal and attached gingiva or interdental papilla. In severe cases, the excess tissue may cover the crowns of the teeth, thus causing functional, esthetic, and periodontal problems, such as bone loss and bleeding, due to the presence of pseudopockets and plaque accumulation. It affects both genders equally.

An Evaluation of Halitosis using Oral Chroma™ Data Manager, Organoleptic Scores and Patients' Subjective Opinions.

Background: Halitosis or breath odor, is defined as an unpleasant or offensive odor emanating from the mouth. Three forms are distinguished: genuine halitosis, pseudohalitosis and halitophobia. The source of 85% of all cases of halitosis lies in the oral cavity.

[Local complications of lip and tongue piercing -- report of the cases].

Piercing, which is the form of puncturing parts of the human body and creating openings where jewelry can be worn, is together with tattoos, body drawings or make-up, one of the oldest way of decorating of the human body. Piercing can be performed in each part of the body. In the recent years face piercing (nose, eyebrows, lip region) and in the oral cavity (tongue, lips, cheek, mentolabial sulcus, labial frenulum) is becoming particularly popular.

[Nutrition and periodontal diseases].

The aim of this paper is to review the available literature pertaining the influence of specific nutritional elements (e.g. vitamin C, vitamin B-complex and dietary calcium) on periodontal status.