Publications by authors named "Katarzyna Haynesworth"
Article Synopsis
- Serology testing is vital for assessing the effectiveness of COVID-19 vaccines and detecting past infections by measuring antibodies against SARS-CoV-2.
- This study validated four laboratory-developed serology tests for antibodies (IgG and IgM) against Spike and Nucleocapsid proteins, ensuring they met strict Clinical and Laboratory Standards Institute (CLSI) guidelines for reliability.
- Results showed good linearity and precision across the tests, demonstrating their validity for identifying levels of antibodies, which is crucial for ongoing COVID-19 research and management.
Article Synopsis
- SARS-CoV-2 serology is important for assessing COVID-19 vaccine effectiveness and immune response, but factors like tube type and anticoagulant can affect results.
- The study found no significant differences in antibody levels based on tube type; however, tubes with anticoagulants sodium citrate and ACD showed lower antibody concentrations, which were mostly adjusted after considering dilution factors.
- There were noticeable differences in IgG avidity between plasma and serum, suggesting that plasma treated with anticoagulant cannot be considered interchangeable with serum for certain assays, warranting further exploration.
Vaccines (Basel)
May 2024
Article Synopsis
- SARS-CoV-2 vaccination leads to changes in antibody levels and characteristics, which can influence protection against infection.
- After the initial vaccine series, IgG levels decrease over time while antibody avidity (binding strength) increases; however, this trend is reversed after a third booster dose, which boosts both IgG levels and avidity.
- Comparison between the two mRNA vaccines shows that one (BNT162b2) results in higher antibody avidity than the other (mRNA-1273) six months after the third dose.
Microbiol Spectr
March 2023
Article Synopsis
- * The assay's performance was assessed using samples from both negative controls and PCR-confirmed cases, confirming its accuracy, precision, and lack of interference between different antigens.
- * Results are reported in terms of antibody concentrations aligned with WHO standards, making this assay an effective tool for studying immunity and vaccine responses in the context of SARS-CoV-2.
