Publications by authors named "Katarzyna Gwardiak"
The rearrangements of dihydrobetulin, dihydrobetulinic acid, and -lupane epoxides under acidic conditions (HCl, montmorillonite K10, and BF·EtO) were studied. The treatment of dihydrobetulin with HCl or K10 produced -lupane olefins. Their epoxidation afforded epoxides, which, in the presence of protic or Lewis acids, rearranged to dienes or lupanes bearing a bicyclo[3.
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- * The text outlines a new method for synthesizing betulin bidesmosides, which are under-researched due to challenging preparation techniques.
- * Testing reveals that the presence of an l-rhamnose sugar enhances the anticancer effectiveness of these compounds, while an l-arabinose fragment reduces it, indicating their potential as viable cancer treatments.
Synthesis of lupane bidesmosides was optimized. The title compounds were obtained by glycosylation of 3-O- or 28-O-substituted betulin monodesmosides with Schmidt donors catalyzed by TMSOTf. Classical batch procedure and microreactor technique were used and compared in the above synthesis.
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