Publications by authors named "Katarzyna Czarnota"
Currently, many new possible biomarkers and mechanisms are being searched and tested to analyse pathobiology of pediatric tumours for the development of new treatments. One such candidate molecular factor is (BRCA1 Associated RING Domain 1)-a tumour-suppressing gene involved in cell cycle control and genome stability, engaged in several types of adult-type tumours. The data on significance in childhood cancer is limited.
View Article and Find Full Text PDFIntroduction: Germ cell tumours (GCTs) in the children comprise a group of tumours that originate from primordial germ cells but their pathogenesis is not clear. Intracranial GCTs represent a special subset of these paediatric neoplasms. Hedgehog (Hh) pathway gene status in GCTs is generally unexplored, while Hh signalling is involved in germ cell biology.
View Article and Find Full Text PDFArticle Synopsis
- The article reviews rare neuroectodermal-type lesions in the female genital tract and discusses their connection to systemic pathology.
- It presents two unusual cases: an endometrial glial polyp in a young woman and a mature cystic teratoma with peritoneal gliomatosis in an adolescent girl.
- Both cases required thorough diagnostic approaches, including careful sampling, immunophenotyping, and consultation with neuropathology experts.