Publications by authors named "Katarzyna Czapla"
Article Synopsis
- The study investigates how three nonsteroidal anti-inflammatory drugs (oxicams: meloxicam, piroxicam, tenoxicam) affect the properties of certain lipid monomolecular films.
- Using techniques like surface pressure measurements and infrared spectroscopy, researchers found that the oxicams alter aspects such as hydration and molecular orientation within the lipid layers.
- The activity of the enzyme phospholipase A2 was affected by the presence of these drugs, suggesting that their anti-inflammatory effects may involve both interference with this enzyme and traditional cyclooxygenase inhibition.
Meloxicam, piroxicam, and tenoxicam belong to a highly potent oxicam group of nonsteroidal anti-inflammatory drugs. Whereas the structurally similar oxicams have different pharmacokinetics, treatment efficiency, and adverse effects, their common mechanism of action is the inhibition of a membrane enzyme, cyclooxygenase. Because the prerequisite for accessing the cyclooxygenase by the drugs is interaction with the membrane, the focus of the current study was a comparison of how meloxicam, piroxicam, and tenoxicam interact with lipid monolayers used as models of biological membranes.
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