Ubiquitin-specific protease 7 as a potential therapeutic target in dogs with hematopoietic malignancies.

Background: Ubiquitin-specific protease 7 (USP7) belongs to the group of deubiquitinating enzymes (DUBs), which remove ubiquitin which controls various cellular processes such as chromosome segregation, DNA repair, gene expression, protein localization, kinase activity, protein degradation, cell cycle progression, and apoptosis. It is critical for several important functions in the cell, and therefore dysregulation of USP7 can contribute to tumorigenesis.

Objectives: Alterations in the USP7 protein have been identified in various malignancies of humans.