The risk of mental disorders in patients with disorders/differences of sex differentiation/development (DSD) and Y chromosome.

Introduction: Patients with disorders/differences of sex differentiation/development (DSD) are exposed to physical and mental suffering. The aim of the study was to assess the following: the mental health status and the risk of mental problems in adult DSD patients, their dependence on therapeutic procedures, and to identify groups of disorders that require particular psychological support.

Material And Methods: The study involved 59 patients with DSD (gonadal dysgenesis - GD, androgen insensitivity syndrome - AIS, 5-alpha reductase deficiency, ovotestis), and with the Y chromosome in the karyotype, aged 16-65 years.

[Therapeutic problems in disorders of sex development].

The compatibility between genetic, gonadal, genital, somatic and psychic sex should be present for the proper sexual development. If there is no such compatibility, disorders of sex development (DSD) appear. Medical procedure in such cases leads to many problems which mainly come from the lack of sufficient knowledge about the pathophysiology of the disorders.