Publications by authors named "Katarzyna A Brzezicka"
Article Synopsis
- Autoimmune diseases affect over 4% of people worldwide, and current treatments mainly focus on reducing symptoms and suppressing the immune system.
- Researchers developed hybrid nanoparticles that can promote tolerance in T and B cells, using a combination of a lipid layer, a PLGA core with rapamycin, and specific proteins to target immune responses.
- In experiments with mice, these nanoparticles successfully induced tolerance to a specific antigen, leading to delayed onset of rheumatoid arthritis and lower antibody levels, showcasing their potential as a new treatment strategy for autoimmune diseases.
Mol Aspects Med
April 2023
Article Synopsis
- - Autoimmune diseases impact millions in the U.S., primarily treated with symptom management rather than cures, as they result from an imbalance in immune system functions.
- - The pathogenesis involves autoreactive B and T cells attacking the body’s own tissues, with Siglecs emerging as promising immune checkpoints for new therapies.
- - The review emphasizes the roles of Siglecs like CD22 and Siglec-10 in modulating immune responses and discusses potential strategies for restoring immune tolerance and developing biomarkers for monitoring autoimmune conditions.
Nanoscale Res Lett
November 2018
Article Synopsis
- * New technologies have been developed to analyze these complex glycan recognition events.
- * This study presents the creation of fluorescent gold nanoclusters that are functionalized with neoglycoproteins, which are effective for detecting plant lectins and for imaging dendritic cells in lab settings.
