Endodontic treatment modifies circulatory inflammatory mediator levels: A systematic review with meta-analysis.

Background: There is limited and conflicting data on the reduction of circulatory inflammatory mediators in patients with apical periodontitis (AP) following endodontic treatment.

Objective: To answer the following research question: in adult healthy patients with AP [Population (P)], is there a difference before [Comparator (C)] and after various endodontic treatments (nonsurgical, surgical or retreatment) [Intervention (I)] on systemic levels of inflammatory biomarkers [Outcome (O)] in the follow-up period [Time (T)]?

Methods: An electronic literature search was conducted in the databases Scopus, PubMed, Clarivate Analytics' Web of Science, Cochrane Database of Systematic Reviews and Grey literature from inception to July 2024 with no language restrictions. Observational studies examining changes in serum levels of inflammatory mediators were included.

Influence of irrigation and laser assisted root canal disinfection protocols on dislocation resistance of a bioceramic sealer.

Background: It is not yet clear how different irrigation protocols and intracanal laser irradiation effects bioceramic sealers. In this vitro study, we aimed to evaluate the dislocation resistance of a bioceramic root canal sealer after different laser-assisted disinfection protocols and irrigants.

Methods: Sixty extracted human straight single-canal teeth were instrumented, and randomly divided into five experimental groups (n=10) according to the disinfection protocol used: group 1, conventional needle irrigation (CI) with sodium hypochlorite (NaOCl)+ethylenediaminotetraacetic acid (EDTA)+NaOCl; group 2, Photon initiated photoacoustic streaming (PIPS) of NaOCl+EDTA+NaOCl; group 3, NaOCl+EDTA+diode laser; group 4, NaOCl+EDTA+photodynamic therapy (PDT); group 5, CI with NaOCl+EDTA+Chlorhexidine (CHX); and control group without any treatment.

ENDODONTIC PERIAPICAL LESIONS ARE CHARACTERIZED WITH THE HIGH PREVALENCE OF VIABLE AND ACTIVEMICROORGANISMS.

Article Title And Bibliographic Information: Bronzato JD, Bomfim RA, Hayasida GZP, Cúri M, Estrela C, Paster BJ, Gomes BPFA. Analysis of microorganisms in periapical lesions: A systematic review and meta-analysis. Arch Oral Biol.

Prevalence of Apical Periodontitis and Conventional Nonsurgical Root Canal Treatment in General Adult Population: An Updated Systematic Review and Meta-analysis of Cross-sectional Studies Published between 2012 and 2020.

Introduction: This study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.

Methods: An electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language.

Notch - a possible mediator between Epstein-Barr virus infection and bone resorption in apical periodontitis.

This study aimed to investigate whether Epstein-Barr virus (EBV) positive periapical lesions exhibited higher mRNA levels of Notch signalling molecules (Notch2 and Jagged1), bone resorption regulators (receptor activator of nuclear factor kappa-β ligand (RANKL) and osteoprotegerin (OPG)), and proinflammatory cytokines (tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and IL-6) compared to EBV negative lesions. Additionally, the potential correlation between investigated molecules in periapical lesions was analyzed. Sixty-four apical periodontitis lesions were obtained subsequent to standard apicoectomy procedure.

Notch signaling pathway mediates alveolar bone resorption in apical periodontitis.

Apical periodontitis represents a chronic inflammatory process within periapical tissues, mostly caused by etiological agents of endodontic origin. Progressive bone resorption in the periapical region represents the hallmark of apical periodontitis and occurs as the consequence of interplay between polymicrobial infections and host response. The Notch signaling pathway is an evolutionary conserved cell-signaling system that plays an important role in a variety of cell functions including proliferation, differentiation and apoptosis.

Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines.

Introduction: The exact mechanisms of periapical bone resorption have not been fully elucidated. This study aimed to analyze the expression of Notch signaling molecules (Notch2, Jagged1, and Hey1) and proinflammatory cytokines (tumor necrosis factor alpha [TNF-α], interleukin [IL]-1β, and IL-6) in human apical periodontitis lesions with different receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG) ratios and determine their potential correlation.

Methods: The study group consisted of 50 periapical lesions collected in conjunction with apicoectomy.

The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review.

Introduction: Varicella zoster virus (VZV) and subsequent herpes zoster (HZ) infection have been proposed as a causative agent of periapical pathoses and root resorption. This review aimed to identify, synthesize, and present a critical analysis of the available data on the association among VZV, subsequent HZ infection, and the development of periapical pathoses and root resorption and to analyze the level of evidence of available studies.

Methods: The literature search covered MEDLINE, Science Citation Index Expanded, and Scopus.

Herpesviral-bacterial co-infection in mandibular third molar pericoronitis.

Objective: The aim of this study was to assess the presence of herpesviruses and periodontopathic bacteria and to establish their potential association with pericoronitis.

Materials And Methods: Fifty samples obtained with paper points (30 from pericoronitis and 20 controls) were subjected to polymerase chain reaction (PCR) analysis. A single-stage and nested PCR assays were used to detect herpesviruses: human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) and six periodontopathic anaerobic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Parvimonas micra, Treponema denticola, and Tannarella forsythia.

Epstein-Barr virus infection induces bone resorption in apical periodontitis via increased production of reactive oxygen species.

Chronic inflammatory processes in periapical tissues caused by etiological agents of endodontic origin lead to apical periodontitis. Apart from bacteria, two herpesviruses, Epstein-Barr virus (EBV) and Human cytomegalovirus (HCMV) are recognized as putative pathogens in apical periodontitis. Although previous reports suggest the involvement of EBV in the pathogenesis of apical periodontitis, its exact role in periapical bone resorption has not yet been fully elucidated.

[Morphological characteristics of mesiobuccal root canals of the first maxillary molars].

Introduction: The first maxillary molar is a tooth with three roots, and mesiobuccal one is with the most complex canal morphology. Factors influencing variations of its morphology are numerous, and may significantly complicate endodontic treatment.

Objective: The objective was to investigate the number, configuration and curvature orientation of the mesiobuccal root canals in the maxillary first molars.