Antitumour effectiveness of hyperthermia is potentiated by local application of electric pulses to LPB tumours in mice.

Background: The aim of our study was to determine whether local application of electric pulses to tumours, which induce transient reduction of tumour perfusion, could potentiate the antitumour effectiveness of hyperthermia.

Materials And Methods: The antitumour effectiveness of local application of electric pulses (1300 V/cm, 100 micros, 1 Hz) and 910 MHz local hyperthermia at 43.5 degrees C, alone or in combination, was determined on LPB tumours in C57Bl/6 mice by measurement of tumour growth delay, changes in tumour perfusion using the Patent blue technique and extent of tumour necrosis.