Rationale: Polarity proteins are involved in the apico-basal orientation of epithelial cells, but relatively little is known regarding their function in mesenchymal cells.
Objective: We hypothesized that polarity proteins also contribute to endothelial processes like angiogenesis.
Methods And Results: Screening of endothelial cells revealed high expression of the polarity protein Scribble (Scrib).
Arterioscler Thromb Vasc Biol
February 2009
Objective: Insulin promotes differentiation of preadipocytes into adipocytes. Insulin also stimulates reactive oxygen species (ROS) production, and the NADPH oxidases Nox1 and Nox4 are important sources of ROS. We determined in human and mouse preadipocytes whether Nox proteins contribute to ROS formation and differentiation in response to insulin.
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