Endoscopic treatment of gastric antral vascular ectasia in real-life settings: Argon plasma coagulation or endoscopic band ligation?

Objective: The efficacy of argon plasma coagulation (APC) on gastric antral vascular ectasia (GAVE) may be impaired over time and depends greatly on the application settings. Endoscopic band ligation (EBL) may be an alternative, but study on its efficacy is limited. This study aimed to evaluate and compare the clinical efficacy of APC and EBL in treating GAVE.

Antibody and cell-mediated immune response to whole virion and split virion influenza vaccine in patients with inflammatory bowel disease on maintenance immunosuppressive and biological therapy.

Objective: Influenza vaccination is recommended for inflammatory bowel disease (IBD) patients on immunosuppressive therapy. The objective was to evaluate the antibody and cell-mediated immune response to the split and whole virion influenza vaccine in patients with IBD treated with anti-TNF-α and immunosuppressive therapy.

Patients And Methods: One hundred and fifty-six immunocompromised IBD patients were vaccinated.

[Vitamin D level in Hungarian patients with inflammatory bowel diseases].

Introduction: Vitamin D has an important role in the immune regulation. Vitamin D is essential for innate and adaptive immune systems and it plays a significant role in the formation of immune tolerance, as well.

Aim: Vitamin D deficiency has been observed in patients with inflammatory bowel diseases in Western Europe, but there is no data available from Eastern Europe.

Does dermatitis herpetiformis result in bone loss as coeliac disease does? A cross sectional study.

Introduction And Objectives: coeliac disease (CD) and its cutaneous manifestation, dermatitis herpetiformis are both (DH) gluten-sensitive diseases. Metabolic bone disease is common among patients with CD, even in asymptomatic forms. Data are scarce about bone density in patients with dermatitis herpetiformis.

[Prevalence of gastric polypoid lesions at an endoscopic facility].

Background: The prevalence of gastric polyps is unknown in Hungary.

Aim: The aim of the authors was to assess the prevalence of polypoid lesions of the stomach in the endoscopic centre of the 2nd Department of Medicine, Semmelweis University.

Methods: Results of upper gastrointestinal endoscopies carried out between March 2010 and June 2011 were analysed.

Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral centre.

Aims: The aim of this study is to evaluate the experience of a single coeliac centre over a 15-year-long study period (between November of 1997 and September of 2011).

Patients And Methods: Charts of 178 patients (139 females) with coeliac disease were retrospectively evaluated. Tests performed: multiple duodenal biopsies, anti-tissue transglutaminase and anti-endomysium antibodies, body mass index calculation, osteodensitometry, evaluation of disorders associated with coeliac disease, and implementation of family screening.

[Hungarian data on inflammatory bowel diseases: analytical data on ulcerative colistis].

Unlabelled: Prospective data collection seems to be essential in evidence-based medicine. Because of the new therapeutic options, the need for standard data collection and testing has significantly increased. In Hungary, a registry for patients with inflammatory bowel disease has already been set up, which makes it possible for clinicians to collect prospective data on their patients.

[Epidemiology, predictors and clinical aspects of loss of response to biological therapy].

In the last two decades, the treatment paradigms for Crohn's disease and ulcerative colitis have significantly changed inclusive of a continuously increasing role of biological therapy (anti TNFs). Some patients, however, experience lack or loss of response to biological treatment, and in such cases the management of patients is often empirical. In this review, the authors aim to summarize the available data regarding epidemiology and predictors of loss of response to biological therapy considering the clinical factors and the relationship between serum concentrations, antibodies against biological agents, respectively.

Anti-TNF trough levels and detection of antibodies to anti-TNF in inflammatory bowel disease: are they ready for everyday clinical use?

Introduction: In the last two decades, with the development of biological (anti-TNFα) therapy, the treatment paradigms for Crohn's disease and ulcerative colitis have evolved, with a continuously increasing role of biologicals. Some patients, however, experience lack- or loss of response (LOR) to treatment, and management of such patients is often empirical.

Areas Covered: The available data regarding the relationship between serum anti-TNF concentrations, antibodies against anti-TNF agents, and clinical efficacy, as well as the development of adverse events and management of LOR.

Low bone mass in microscopic colitis.

Background: Microscopic colitis presents with similar symptoms to classic inflammatory bowel diseases. Osteoporosis is a common complication of Crohn's disease but there are no data concerning bone metabolism in microscopic colitis.

Aims: The aim of the present study was to evaluate bone density and metabolism in patients with microscopic colitis.

Clinical relevance of changes in bone metabolism in inflammatory bowel disease.

Low bone mineral density is an established, frequent, but often neglected complication in patients with inflammatory bowel disease (IBD). Data regarding the diagnosis, therapy and follow-up of low bone mass in IBD has been partially extrapolated from postmenopausal osteoporosis; however, the pathophysiology of bone loss is altered in young patients with IBD. Fracture, a disabling complication, is the most important clinical outcome of low bone mass.

[Prevalence of childhood asthma in Baranya County, Hungary, between 2003 and 2006].

Introduction: The prevalence of bronchial asthma, allergic rhinitis and atopic dermatitis (AD) in children has constantly and significantly increased worldwide in the past decades. Recent publications, however, reported a moderate decrease or levelling off in this parameter. The authors estimated the prevalence of bronchial asthma and asthmatic complaints among schoolchildren in Baranya county in the years 2003 and 2006 in order to register the possible changes.

[Prevalence of atopic dermatitis in school children of Baranya county].

Introduction: The prevalence of atopic dermatitis (AD) in children has significantly increased worldwide in the past decades. Although it is well known that the number of AD patients has also been growing in Hungary no prevalence studies on a given population have been performed so far.

Methods: The present research investigated the prevalence of AD in school children by means of questionnaires.