[VARICOSE VEINS OF PELVIS IN ELDERLY WOMEN AS ACTUAL PROBLEM IN GERIATRICS].

The article presents an overview of the problem of varicose veins of pelvic (VVP) in elderly women. VVP is severe suffering to women, especially in the elderly, it promotes social exclusion, leads to psychoemotional disorders and occurrence of chronic pelvic pain due to pelvic varicose veins transformation. Despite the 150-year history of the disease, there is still no clear understanding of the clinical picture of the disease and, most importantly, how to treat this condition.

[Gene expression of vascular endothelial growth factors and their receptors in different variants of the course of multiple myeloma].

Aim: To determine the significance of the angiogenic activity estimated from the gene expression of the vascular endothelial growth factors (VEGFs) VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR1, VEGFRls, VEGFR2, and VEGFR3 in the mononuclear cell fraction of bone marrow (BM) aspirates with tumor plasma cells predominating in different variants of the course of multiple myeloma (MM).

Materials And Methods: The gene expression of VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFRI, VEGFRls, VEGFR2, and VEGFR3 was determined by reverse-transcription polymerase chain reaction (RT-PCR).

Results: VEGF-A, VEGF-C, VEGF-D, as well as VEGFR1, VEGFRls, VEGFR2, and VEGFR3 were expressed showing different intensities in the mononuclear cell fraction of BM aspirates with a predominance of tumor plasma cells in the patients with MM, which allowed patient groups to be identified.

[Effectiveness of bortezomib and bortezomib-containing programs for the treatment of recurrent and resistant multiple myeloma].

Aim: To evaluate the effectiveness of bortezomib and bortezomib-containing treatment programs in the therapy of resistant and recurrent multiple myeloma (MM) within a large unicenter study in real clinical practice conditions.

Subjects And Methods: The study enrolled 101 patients (48 men and 53 women aged 34 to 77 years, mean age 54 years) with resistant and recurrent MM. According to the types of paraprotein (PIg), the authors revealed the usual distribution: G, 60.

[Characteristics of drug resistance of tumor plasmocytes in vitro in patients with multiple myeloma differently responsive to chemotherapy].

Aim: To determine sensitivity of tumor plasmocytes in vitro to cytostatic drugs (prednisolone, alkeran belustin, vincristine, rubomycin, doxorubicin, cytarabin, methotrexate, cysplatin, etoposide).

Material And Methods: The sensitivity was measured with DISC method in 12 patients with multiple myeloma (MM) in two groups: resistant and responsive to induction polychemotherapy (PCT).

Results: The groups appeared significantly different by lowering of pathological paraprotein concentration (PIg): by 7.

[A trial of using psychotherapy in the sanatorium on servicemen with psychosomatic pathology of the cardiac system].

Administration of rehabilitation psychotherapy, including pathogenetic and symptomatic psychotherapy, raises efficacy of combined sanatorium treatment of early stages of such cardiological diseases as ischemic heart disease, angina of effort class I, essential hypertension stage I. Psychotherapy also promotes relief of psychoemotional stress, anxiety, frustration, rigidity, aggression, alexithymia, asthenia being primary and secondary prophylaxis of psychosomatic disorders.