External Quality Assessment of Sputum Smear Microscopy in Tuberculosis Laboratories in Sughd, Tajikistan.

Introduction: Tajikistan has a laboratory network with three levels of tuberculosis (TB) laboratories. The external quality assessment (EQA) of sputum smear microscopy was implemented in 2007. The objective of this study was to evaluate the EQA system and identify potential performance improvement strategies in TB microscopic laboratories in Sughd, Tajikistan.

[Effect of ronkoleukin on nitric oxide and lipid peroxidation indices in hepatocarcinogenesis].

Hepatocarcinogenesis induced by DENA lead to increase in NO2 level, decrease in L-Arginin and Malonic Di-aldehyde (MDA) levels. The use of doksorubicyn slightly increases L-Arginin level in blood serum in mice without affecting considerably nitrite levels. Doksorubicin application in combination with ronkoleukin enables profound consumption of L-Arginin, increases nitrite levels and MDA.

[Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators].

Structural changes of thymus in heliotrin hepatitis were characterized by distinct dynamics which on the whole suggested the progressing hypoplasia of its cortex. Immunostimulants parandin and thymalin suppressed the extent of thymocyte destruction and stimulated their mitotic activity. Although these parameters did not reach the control levels, the significant deceleration of hypoplastic processes in thymus, particularly in its cortex, were detected.

[Social and hygienic characteristics of health of young athletes].

A complex sociohygienic study carried out at two republican Olympic reserve athletic colleges and three athletic schools for children revealed specific features in the life style and conditions of life of young athletes, helped define the pattern of their morbidity and health status.

[Characteristics of child morbidity in large families in rural areas of Kazakhstan].

During the 3-year trial period health status of 1233 children in 408 large families was studied in rural areas of Kazakhstan. 49.5% of those families had 4 and more children.

[Fucosylation of serum proteins in stomach cancer].

Content of fucose and of fucosylated protein fractions was studied in blood serum of healthy donors as well as in blood serum of patients with chronic gastritis and with stomach cancer. Concentration of fucose was increased in blood serum under conditions of the tumor generalization. At the same time, content of fucosylated albumin was elevated within early steps of stomach cancer, while the content of fucosylated globulins was decreased.

[The degree of modification of serum albumin as a toxicological test].

A procedure is developed, involving electrophoresis and TCA-ethanol treatment of electrophoregramms, which enabled to estimate quantitatively the modified derivatives of albumin just in blood serum without the protein isolation. The method is based on ability of native albumin to maintain its solubility after TCA-ethanol treatment. At the same time, modified albumin with conformational alterations was fixed on a carrier and might be estimated using colorimetry or densitometry.

[Phospholipid composition and oxidative phosphorylation in liver mitochondria in hepatitis].

Phospholipid composition and oxidative phosphorylation were studied in liver mitochondria of rats with experimental chronic hepatitis. The hepatitis was simulated by means of two hepatotropic drugs--heliotrin and CCl4. Content of phosphatidyl inositol was decreased and that of phosphatidic acid--increased in the hepatitis independently of the nature of the agent inducing the disease.

[Properties of human serum albumin in ischemic heart disease].

Conformational changes in blood serum albumin under heart ischemia are found from the dispersion parameters of optical rotation and circular dichroism. It is also found that patients with myocardium infarction have a considerable amount of carbohydrate components in the modified albumin form.

[Transient form of serum albumin in gynecologic cancer].

The frequency of diagnostic errors in examination of 3827 patients with gynecological cancer diseases accounted for 21.6 up to 35%. The conformation of serum albumin in these patients was studied by means of different biochemical assays.