The influence of direct compression powder blend transfer method from the container to the tablet press on product critical quality attributes: a case study.

Objective: The aim of this article is to compare the gravitational powder blend loading method to the tablet press and manual loading in terms of their influence on tablets' critical quality attributes (CQA).

Significance: The results of the study can be of practical relevance to the pharmaceutical industry in the area of direct compression of low-dose formulations, which could be prone to content uniformity (CU) issues.

Methods: In the preliminary study, particle size distribution (PSD) and surface energy of raw materials were determined using laser diffraction method and inverse gas chromatography, respectively.

Evaluation of drug-carrier interactions in quaternary powder mixtures containing perindopril tert-butylamine and indapamide.

Interactions occurring between components in the quaternary powder mixtures consisting of perindopril tert-butylamine, indapamide (active pharmaceutical ingredients), carrier substance and hydrophobic colloidal silica were examined. Two grades of lactose monohydrate: Spherolac(®) 100 and Granulac(®) 200 and two types of microcrystalline cellulose: M101D+ and Vivapur(®) 102 were used as carriers. We determined the size distribution (laser diffraction method), morphology (scanning electron microscopy) and a specific surface area of the powder particles (by nitrogen adsorption-desorption).

Preparation of hybrid materials for controlled drug release.

Authors obtained hybrid organic-inorganic materials applied in sustained drug delivery. The materials are ibuprofen as a model drug, hydroxyapatite and three different polymers as supports. Influence of the type of employed polymer, an inorganic carrier, on the properties and drug release profiles was estimated.

Relationship between surface properties determined by inverse gas chromatography and ibuprofen release from hybrid materials based on fumed silica.

The ability of organic-inorganic hybrid materials to act as drug release-modifying agents was examined. In this study, ibuprofen, a non-steroidal anti-inflammatory drug was used as a model active pharmaceutical ingredient. The physicochemical properties of individual components of the hybrids, as well as these for two- and three-component systems were examined by inverse gas chromatography.

Inverse gas chromatography as a source of physiochemical data.

Inverse gas chromatography (IGC) is presented as a useful method for the examination of physicochemical properties of various materials. The advantages of IGC are presented. However, the uncertainties and sources of possible errors are also indicated and discussed.

Characterization of the interactions in polymer-filler systems by inverse gas chromatography.

Inverse gas chromatography (IGC) has been applied to observe the interactions in filled polymer-organic solvent as well as modified filler-polymer systems under conditions approaching infinite dilution of the volatile component. We investigated polyether-urethane-modified silica systems containing different kinds of modified silicas (filler) at 10% w/w loading. The fillers were modified with N-2-aminoethyl-3-aminopropyltrimethoxysilane (B2), 3-aminopropyltriethoxysilane (B3), 3-mercaptopropyl-trimethoxysilane (B4), n-octyltriethoxysilane (B5).