Publications by authors named "Kasumi Nakamura"
This study was conducted to determine if dietary supplementation with coenzyme Q (CoQ ), which can act as a potent antioxidant and is an obligatory cofactor of mitochondrial uncoupling protein, suppresses the heat stress (HS)-induced overproduction of mitochondrial reactive oxygen species (ROS) and oxidative damage in the skeletal muscle of birds. The carbonyl protein content of skeletal muscle was significantly higher in birds exposed to HS treatment (34°C, 12 h) than in thermoneutral birds (25°C). This increase was suppressed by CoQ supplementation (40 mg/kg diet).
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- The Foxc2 protein is crucial for cardiovascular development, with Foxc2 null mice exhibiting severe heart defects that mirror some human congenital heart diseases.
- The study explores how Foxc2 is expressed in certain cells important for developing the aortic arch, using a conditional knockout strategy to analyze its specific roles.
- Results reveal that loss of Foxc2 in certain cell populations leads to significant heart defects, while its deletion in a different type of endothelial cell results in death from fluid accumulation rather than heart issues.
Article Synopsis
- The ubiquitin-proteasome pathway is crucial for regulating cell death (apoptosis) and the cell cycle, with proteasome inhibitors showing promise in cancer treatment, especially in multiple myeloma.
- Some flavones, like apigenin and chrysin, are known to inhibit proteasome activity and induce apoptosis, but research on other flavones is limited.
- In a study, specific flavonoids (5,6,7-trihydroxyflavone, baicalein, and scutellarein) were tested, revealing that baicalein and scutellarein do not inhibit proteasome activity, indicating that certain hydroxy group configurations are ineffective against the