IgG4-related pancreatobiliary diseases could be associated with onset of pancreatobiliary cancer: A multicenter cohort study.

Background: The risk and prognosis of pancreatobiliary cancer and in patients with autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC) remain unclear. Therefore, we retrospectively investigated the risk of pancreatobiliary cancer and prognosis in patients with AIP and IgG4-SC.

Methods: Patients with AIP and IgG4-SC at seven centers between 1998 and 2022 were investigated.

Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS.

Tumor cells evade targeted drugs by rewiring their genetic and epigenetic networks. Here, we identified that inhibition of MAPK signaling rapidly induces an epithelial-to-mesenchymal transition program by promoting re-localization of an apical-basal polarity protein, Scribble, in oncogene-addicted lung cancer models. Mis-localization of Scribble suppressed Hippo-YAP signaling, leading to YAP nuclear translocation.

Clinical Features and Prognostic Impact of Pancreatic Ductal Adenocarcinoma without Dilatation of the Main Pancreatic Duct: A Single-Center Retrospective Analysis.

The presence of main pancreatic duct (MPD) dilatation is important for diagnosing pancreatic ductal adenocarcinomas (PDACs). However, we occasionally encounter PDAC cases without MPD dilatation. The objectives of this study were to compare the clinical findings and prognosis of pathologically diagnosed PDAC cases with and without MPD dilatation and to extract factors related to the prognosis of PDAC.

Detectability of pulmonary nodules on chest radiographs: bone suppression versus standard technique with single versus dual monitors for visualization.

Purpose: To evaluate the diagnostic accuracy of bone suppression imaging (BSI) in the detection of pulmonary nodules on chest radiographs (CXRs) and the effect of visualization method (single or dual monitors) on diagnostic accuracy.

Materials And Methods: Ten observers interpreted the CXRs of 100 patients: 50 with a T1 lung cancer nodule and 50 without nodules. Each standard CXR was first read alone and then in combination with the corresponding BSI.

Low-Frequency Electrical Stimulation of Denervated Skeletal Muscle Retards Muscle and Trabecular Bone Loss in Aged Rats.

Electrical stimulation (ES)-induced muscle contraction has multiple effects; however, mechano-responsiveness of bone tissue declines with age. Here, we investigated whether daily low-frequency ES-induced muscle contraction treatment reduces muscle and bone loss and ameliorates bone fragility in early-stage disuse musculoskeletal atrophy in aged rats. Twenty-seven-month-old male rats were assigned to age-matched groups comprising the control (CON), sciatic nerve denervation (DN), or DN with direct low-frequency ES (DN+ES) groups.

Dataset of polyoxometalate-assisted -heterocyclic carbene gold(I) complexes.

The present paper is the Supplemental materials for our original paper entitled "highly active, homogeneous catalysis by polyoxometalate-assisted -heterocyclic carbene gold(I) complexes for hydration of diphenylacetylene. The present article refers to the preparations of several monomeric, -heterocyclic (NHC) carbene/carboxylate (-pyrrld)/gold(I) complexes, [Au(-pyrrld)(NHC)] (NHC = IMes (), BIPr (), IF (), IBu ()), which were used for homogenous catalysis of the hydration reaction of diphenylacetylene to afford deoxybenzoin. The article also includes the preparations of the precursor complexes, [AuCl(NHC)] (NHC = IPr, IMes, BIPr, IF, IBu), and novel X-ray crystallography of the separately prepared [Au(IPr)(HO)][α-PWO]·7EtO (), summary of crystal data of (), and selected bond distances (Å) and angles (deg) of ().

Syntheses, Structures, and Antimicrobial Activities of Gold(I)- and Copper(I)- N-Heterocyclic Carbene (NHC) Complexes Derived from Basket-Shaped Dinuclear Ag(I)-NHC Complex.

Novel dinuclear gold(I)- and copper(I)- N-heterocyclic carbene (NHC, L-1a) complexes [M(L-1a)](PF) (M = Au (Au-1·PF) and M = Cu (Cu-1·PF)) were synthesized by transmetalation of the dinuclear silver(I)-NHC complex [Ag(L-1a)](PF) (Ag-1·PF) with [AuCl(MeS)] or CuI in over 70% yield. These NHC complexes were characterized by CHN elemental analysis, Fourier transform infrared spectroscopy, thermogravimetry/differential thermal analysis, and solution (H and C) NMR spectroscopy. X-ray crystallography revealed that Au-1·PF and Cu-1·PF are dinuclear molecules consisting of two linear intramolecular C-M-C bonds (M = Au and Cu), one M···M interaction, and two metal atoms arranged in a T-shaped geometry; their molecular structures are very similar to the basket-shaped cage structure of the parent complex Ag-1·PF.

Crystal structure of -poly[silver(I)-μ-l-valinato-κ:].

The reaction of AgO with l-valine (l-Hval, CHNO) in a 1:2 molar ratio in water, followed by vapour diffusion, afforded a coordination polymer of the title compound, [Ag(CHNO)] , with N-Ag-O repeat units, which is classified as a type III silver(I) complex with amino acid ligands. The asymmetric unit consists of two independent units of [Ag(l-val)]. In the crystal, the polymeric chains run along [101], and neighbouring chains are linked a weak Ag⋯Ag inter-action and N-H⋯O hydrogen bonds.

Electrical Stimulation of Denervated Rat Skeletal Muscle Ameliorates Bone Fragility and Muscle Loss in Early-Stage Disuse Musculoskeletal Atrophy.

We tested whether daily muscle electrical stimulation (ES) can ameliorate the decrease in cortical bone strength as well as muscle and bone geometric and material properties in the early stages of disuse musculoskeletal atrophy. 7-week-old male F344 rats were randomly divided into three groups: age-matched control group (Cont); a sciatic denervation group (DN); and a DN + direct electrical stimulation group (DN + ES). Denervated tibialis anterior (TA) muscle in the DN + ES group received ES with 16 mA at 10 Hz for 30 min/day, 6 days/week.

Synthesis, characterization, and structure-activity relationship of the antimicrobial activities of dinuclear N-heterocyclic carbene (NHC)-silver(I) complexes.

The three dinuclear silver(I) complexes of N-heterocyclic carbene (NHC) ligands, [Ag(L-1a)](PF)·2CHCN (Ag-1a), [Ag(L-2)](PF)·HO (Ag-2), and [Ag(L-4)](PF)·2CHCN (Ag-4), were synthesized by reactions of AgO with the corresponding PF salt of the NHC precursors indicated as HL-1(PF), HL-2(PF), and HL-4(PF). HL-1(PF), which is the precursor of ligand L-1, was formed as mixed crystals of two geometric isomers, i.e.

Effect of electrical stimulation-induced muscle force and streptomycin treatment on muscle and trabecular bone mass in early-stage disuse musculoskeletal atrophy.

Objectives: The aim was to determine whether daily muscle electrical stimulation (ES) and streptomycin treatment would have positive or negative effects on trabecular bone mass in disuse rats.

Methods: Seven-week-old male F344 rats were randomly divided into five groups of eight animals each: an age-matched control group (CON); a sciatic denervation group (DN); a DN + direct electrical stimulation group (DN+ES); a DN + streptomycin treatment group (DN+SM); and a DN+ES+SM group. The tibialis anterior (TA) muscles in all ES groups were stimulated with 16mA at 10Hz for 30 min/day, six days/week, for one week.

Characteristics of the Localization of Connexin 43 in Satellite Cells during Skeletal Muscle Regeneration In Vivo.

For myogenesis, new myotubes are formed by the fusion of differentiated myoblasts. In the sequence of events for myotube formation, intercellular communication through gap junctions composed of connexin 43 (Cx43) plays critical roles in regulating the alignment and fusion of myoblasts in advances of myotube formation in vitro. On the other hand, the relationship between the expression patterns of Cx43 and the process of myotube formation in satellite cells during muscle regeneration in vivo remains poorly understood.

Packing polymorphism in the crystal structure of 4,5-dimeth-oxy-2-nitro-benzyl acetate.

The title compound, C11H13NO6, shows two polymorphs, orange and yellow forms, both of which crystallize in the space group P21/c. The mol-ecular structures in the two polymorphs are essentially similar and adopt a planar structure, the maximum deviations for the non-H atoms being 0.1836 (13) and 0.

Electrical stimulation of denervated rat skeletal muscle retards trabecular bone loss in early stages of disuse musculoskeletal atrophy.

Objectives: We aimed to determine the intensity of muscle stimulation required to prevent structural failure as well as bone and skeletal muscle loss after denervation-induced disuse.

Methods: Seven-week-old rats (weight, 198-225 g) were randomly assigned to age-matched groups comprising control (CON), sciatic nerve denervation (DN) or direct electrical stimulation (ES) one day later [after denervation] with 4, 8 and 16 mA at 10 Hz for 30 min/day, six days/week, for one or three weeks. Bone architecture and mean osteoid thickness in histologically stained tibial sections and tension in tibialis anterior muscles were assessed at one and three weeks after denervation.

In Vivo Real-Time Imaging of Exogenous HGF-Triggered Cell Migration in Rat Intact Soleus Muscles.

The transplantation of myogenic cells is a potentially effective therapy for muscular dystrophy. However, this therapy has achieved little success because the diffusion of transplanted myogenic cells is limited. Hepatocyte growth factor (HGF) is one of the primary triggers to induce myogenic cell migration in vitro.

Syntheses, structures, and antimicrobial activities of remarkably light-stable and water-soluble silver complexes with amino acid derivatives, silver(I) N-acetylmethioninates.

Reaction of L- and DL-N-acetylmethionine (Hacmet) and Ag(2)O in water at ambient temperature afforded the remarkably light-stable silver complexes {[Ag(L-acmet)]}(n) (1) and {[Ag(2)(D-acmet)(L-acmet)]}(n) (2), respectively. The color of the solids and aqueous solutions of 1 and 2 did not change for more than 1 month under air without any shields. The light stability of these two silver(I) complexes is much higher than that of silver(I) methioninate {[Ag(2)(D-met)(L-met)]}(n) (3) (Hmet = methionine), silver(I) S-methyl-L-cysteinate {[Ag(L-mecys)]}(n) (4), and silver(I) L-cysteinate {[Ag(L-Hcys)]}(n) (5).

Esophageal fibrovascular polyp removed by cervical esophagotomy.

We report a case of esophageal fibrovascular polyp (FVP) removed by cervical esophagotomy. The patient was a 74-year-old man in whom an intraesophageal mass was detected by a chest CT examination during a complete medical check-up. An upper gastrointestinal series showed a large, pedunculated, cervical esophageal mass for which our preoperative diagnosis was a FVP.

In situ real-time imaging of the satellite cells in rat intact and injured soleus muscles using quantum dots.

The recruitment of satellite cells, which are located between the basement membrane and the plasma membrane in myofibers, is required for myofiber repair after muscle injury or disease. In particular, satellite cell migration has been focused on as a satellite cell response to muscle injury because satellite cell motility has been revealed in cell culture. On the other hand, in situ, it is poorly understood how satellite cell migration is involved in muscle regeneration after injury because in situ it has been technically very difficult to visualize living satellite cells localized within skeletal muscle.

Significance of preoperative evaluations of tumor necrosis factor-alpha, the granulocyte/lymphocyte ratio and their correlation with regard to outcome in gastric cancer patients.

Aim: In order to clarify the anti-cancer effects of tumor necrosis factor-alpha (TNFalpha), we examined the relationship between the preoperative evaluations of TNFalpha and the granulocyte/lymphocyte ratio (G/L ratio) in relation to outcome in gastric cancer patients.

Materials And Methods: Peripheral blood samples were taken within 1 week before curative gastrectomy for measurement of TNFalpha and the G/L ratio. Five-year survival was determined in 71 operative gastric cancer cases.

Upregulation of osteogenic factors induced by high-impact jumping suppresses adipogenesis in marrow but not adipogenic transcription factors in rat tibiae.

Jump training is a high-impact training regimen that increases bone volume in young bones. The aim of our study was to determine whether downregulation of adipogenesis that is associated with upregulation of osteogenesis is detected after jump training in growing rat tibiae. Four-week-old rats were jump trained for 1, 2, or 4 weeks for 5 days/week, and the height of jumping progressively increased to 35 cm.