Sphingosine-1-phosphate receptor 3 activation promotes sociability and regulates transcripts important for anxiolytic-like behavior.

We previously demonstrated that sphingosine-1-phosphate receptor 3 (S1PR3) in the medial prefrontal cortex (mPFC) prevents reductions in sociability normally caused by stress. S1PR3 is a ubiquitously expressed G-protein coupled receptor that regulates immune system function, although its regulation of other biological processes is not well understood. Pharmacological activators of S1PR3 might provide important insights for understanding the neural substrates underlying sociability.

Type 2 diabetes mellitus and neurodegenerative disorders: The mitochondrial connection.

The incidence of type 2 diabetes mellitus (T2DM) has increased in our society in recent decades as the population ages, and this trend is not expected to revert. This is the same for the incidence of the main neurodegenerative disorders, including the two most common ones, which are, Alzheimer's and Parkinson's disease. Currently, no pharmacological therapies have been developed to revert or cure any of these pathologies.

Tailoring Chemical Absorption-Precipitation to Lower the Regeneration Energy of a CO Capture Solvent.

Solvent-based CO capture consumes significant amounts of energy for solvent regeneration. To improve energy efficiency, this study investigates CO fixation in a solid form through solvation, followed by ionic self-assembly-aided precipitation. Based on the hypothesis that CO ions may bind with monovalent metal ions, we introduced Na into an aqueous hexane-1,6-diamine solution where CO forms carbamate and bicarbonate.

Effectiveness of Color Coded Diabetic Control Monitoring Charts among Elderly Diabetics Attending Outreach Primary Care Geriatric Clinics in Rural Karnataka: An Open Label Randomized Control Trial.

Introduction: Type 2 diabetes mellitus problem is progressively rising every day. The adherence to the treatment approaches and health-seeking make major difference in case of diabetics particularly elderly. Visual tools improve the involvement of patients in their care, especially among populations with low health literacy.

Next generation nutraceutical from shrimp waste: The convergence of applications with extraction methods.

In recent years considerable progress in health therapy makes a significant improvement in natural nutraceuticals. Shrimp is a valuable natural sea food and is processed by removing head, tail and carapace as waste. The large amounts of waste produced by sea food industries capitulate, recoverable nutraceutical compound astaxanthin.

Study on elder abuse and neglect among patients in a medical college hospital, Bangalore, India.

Elder abuse and neglect is a problem that occurs across all settings and all populations. Elder abuse has many forms, such as abandonment, emotional or psychological abuse, financial or material exploitation, neglect, physical abuse, and sexual abuse. We conducted this research to determine the prevalence of various types of abuse and neglect and their associated factors among elderly patients attending the urban and rural geriatric clinics at a medical college hospital in Bangalore, India.

User-driven health care - answering multidimensional information needs in individual patients utilizing post-EBM approaches: a conceptual model.

Evidence based on average patient data, which occupies most of our present day information databases, does not fulfil the needs of individual patient-centred health care. In spite of the unprecedented expansion in medical information we still do not have the types of information required to allow us to tailor optimal care for a given individual patient. As our current information is chiefly provided in disconnected silos, we need an information system that can seamlessly integrate different types of information to meet diverse user group needs.

Capillary refill time in term neonates: bedside assessment.

Capillary refill time (CRT) is yet to be established as a specific clinical sign of peripheral circulation in neonates. This study was conducted to assess the influence of four body sites used for measurement, interobserver variability, sex, birth weight, age at assessment and room temperature on CRT recorded in healthy term neonates, at bedside. Two observers measured CRT in four different body sites (forehead, chest, palm and heel) of each of 155 healthy term neonates.

Clinico-bacteriological study of neonatal septicemia in Hubli.

Septicemia is a leading cause of neonatal morbidity and mortality in India. In a study of 242 infants with septicemia conducted between March 1996 & June 1997 at Hubli, Karnataka, 43.39% infants had 'very early onset' sepsis (VOS), 40.