Publications by authors named "Kassandra Pinedo"
Article Synopsis
- Sex differences in COVID-19 outcomes show that men experience greater severity and mortality during acute infection, while women are more likely to develop Long Covid (LC).
- The study analyzed blood samples from 45 participants to explore how immune responses differ between men and women in relation to LC development, identifying sex-specific immune pathways.
- Findings revealed that men who later developed LC had increased TGF-β signaling, while women had reduced signaling and elevated RNA associated with autoimmunity during acute infection, indicating distinct immune changes that could inform targeted treatments.
Article Synopsis
- Acute COVID-19 impacts males and females differently, with men experiencing more severe disease and women showing a higher rate of Long COVID (LC) development.
- Researchers used advanced techniques on patient blood samples to identify sex-specific immune responses contributing to LC, finding that males had increased NK cell signaling initially, while females showed signs of autoimmunity later on.
- Both sexes exhibited shared immune dysfunction, characterized by reduced signaling and signs of T cell exhaustion, suggesting potential targets for personalized treatments for LC.
The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence of autoantibodies in non-SARS-CoV-2 infections and critical illness has not yet been reported. We profiled IgG autoantibodies in 267 patients from 5 independent cohorts with non-SARS-CoV-2 viral, bacterial, and noninfectious critical illness. Serum samples were screened using Luminex arrays that included 58 cytokines and 55 autoantigens, many of which are associated with connective tissue diseases (CTDs).
View Article and Find Full Text PDFThe widespread presence of autoantibodies in acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is increasingly recognized, but the prevalence of autoantibodies in infections with organisms other than SARS-CoV-2 has not yet been reported. We used protein arrays to profile IgG autoantibodies from 317 samples from 268 patients across a spectrum of non-SARS-CoV-2 infections, many of whom were critically ill with pneumonia. Anti-cytokine antibodies (ACA) were identified in > 50% of patients infected with non-SARS-CoV-2 viruses and other pathogens, including patients with pneumonia attributed to bacterial causes.
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