Publications by authors named "Kassahun Dires Ayenew"

Rational use of steroids is essential in the long term for improving patient safety. Systemic steroids are important in clinical treatment, but if they are misused, they might have negative effects. This study assessed systemic steroid use and its determinants at Debre Berhan University Hakim Gizawu Teaching Hospital (DBUHGTH), Ethiopia.

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Three-dimensional printing (3DP) has emerged as a game-changing technology in the pharmaceutical industry, providing novel formulation development in the pharmaceutical sector as a whole, which improved patients' individualized therapy. The pediatric population is among the key targets for individualized therapy. Children are a diverse group that includes neonates, infants, and toddlers, each with unique physiological characteristics.

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Heart failure (HF) is a major and growing medical problem and its management is still challenging due to the coexistence of complications, co-morbidity, and medication non-adherence. HF patients who are adherent to their medication have fewer HF exacerbations, improved survival, and lower healthcare expenditure. Adherence to HF medication plays a pivotal role in attaining maximal therapeutic outcomes.

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Introduction: Globally, cervical cancer(CC) is the second most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women. Human papillomavirus (HPV) infection is the leading cause of CC. Persistent infection with HPV accounts for 90% of all CC cases.

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Background: Ethiopians use as immunity enhancers. However, there is no scientific validation conducted so far regarding this claim. The aim of this study was to investigate the in-vivo immunomodulatory activities of essential oils of in mice.

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The inappropriate use of surgical antimicrobial prophylaxis is a common cause for increased risk of morbidity and mortality from surgical site infection in patients who underwent surgical procedures. The study aimed to evaluate surgical antimicrobial prophylaxis prescribing patterns, Surgical Site Infection (SSI), and its determinants in the surgical ward of Debre Berhan Comprehensive Specialized Hospital, northeast Ethiopia. A prospective cross-sectional study was conducted from October 1st 2022 to January 31st, 2023.

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Article Synopsis
  • Local Ethiopians traditionally use Calpurnia aurea for treating skin infections, but scientific evidence on its antibacterial effects is limited.
  • The study conducted aimed to test the antibacterial properties of C. aurea leaf extracts using various extraction methods, revealing that ethanol extracts showed the highest antibacterial activity against several bacterial strains.
  • Results indicated that the crude extract had similar antibacterial effectiveness to gentamicin and that fractionating the extracts improved their efficacy, particularly against the bacteria Pseudomonas aeruginosa and Staphylococcus aureus, highlighting the potential medical benefits of this plant.
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Background: Ethiopians locally treat liver illnesses with A. Americana. Available literature demonstrates this.

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Background: Local Ethiopians regularly use for cosmetic purposes. The plant's safety, however, is not supported by any solid facts. This investigation aimed to evaluate the acute and subacute toxicities of essential oil in mice.

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Introduction: Hospital-acquired infections (HAIs) are public health problems of global concern and are notably prevalent in developing countries. The prevalence of HAI and its associated factors are not well described in the context of Ethiopia. Currently, the nationwide prevalence of HAI and its corresponding associated factors have not been formally reported in Ethiopia.

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