Migraine is a highly prevalent, complex neurological disorder. The burden of disease and the direct/indirect annual costs are enormous. Thus far, treatment options have been inadequate and mostly based on trial and error, leaving a significant unmet need for effective therapies.
View Article and Find Full Text PDFHeadache disorders are common worldwide and often disabling. Until recently, treatments were borrowed from other branches of neurology and medicine. Monoclonal antibodies targeting calcitonin gene-related peptide (CGRP) ligand and receptor, small molecule CGRP receptor antagonist gepants, serotonin agonists, new devices to deliver currently available drugs, and neuromodulation devices have recently been in the forefront of headache treatments that are rather specific for various headache disorders.
View Article and Find Full Text PDFObjective: A review of treatment options for menstrual migraine.
Background: Migraine affects ∼30 million people in the US. A subset of female migraineurs have migraines that are mainly associated with menstruation.
Objective: The current study retrospectively evaluated patient reported outcomes (PROs) collected before and after at least 2 sessions of onabotulinumtoxinA (onabot) injections for chronic migraine. Depression was assessed by the Patient Health Questionnaire-9.
Method: Chronic migraineurs receiving onabot were identified.
Objectives: To evaluate the accuracy of emergency physicians using bedside ultrasound to detect appendicitis (BUSA).
Methods: Patients presenting to the emergency department with a clinical suspicion of appendicitis were prospectively enrolled and received a 5-min BUSA. Patients received routine work-up for acute appendicitis as deemed appropriate by the attending physician.