Characteristics of COVID-19 patients with multiorgan injury across the pandemic in a large academic health system in the Bronx, New York.

Purpose: To investigate the evolution of COVID-19 patient characteristics and multiorgan injury across the pandemic.

Methods: This retrospective cohort study consisted of 40,387 individuals tested positive for SARS-CoV-2 in the Montefiore Health System in Bronx, NY, between March 2020 and February 2022, of which 11,306 were hospitalized. Creatinine, troponin, and alanine aminotransferase were used to define acute kidney injury (AKI), acute cardiac injury (ACI) and acute liver injury, respectively.