Uridine-derived ribose fuels glucose-restricted pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy. This is mediated in part by a complex tumour microenvironment, low vascularity, and metabolic aberrations. Although altered metabolism drives tumour progression, the spectrum of metabolites used as nutrients by PDA remains largely unknown.

Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4.

Voltage-activated Ca(2+) channels comprise complexes of a pore-forming Ca(V)alpha(1) and auxiliary subunits Ca(V)beta, Ca(V)alpha(2)delta and sometimes Ca(V)gamma. The intracellular Ca(V)beta subunit assists in trafficking and surface expression of the Ca(V)alpha(1) subunit and can modulate biophysical properties of the Ca(2+) channel. Four genes, Ca(V)beta1-4, exist which confer different properties to Ca(2+) currents through the various Ca(V)alpha(1) subunits.

[Micturition syncope: a peculiar cause of diagnostic doubt].

A 22-year old healthy man lost consciousness during urination in standing after night's sleep. He fell down to the floor without convulsions. A physician present by chance found on bradycardia.

[Neurocysticercosis: benign natural course].

In a waiter aged 51 without clinical symptoms, but with a history of sporadic epileptic seizures in young age, radiological examination demonstrated multiple calcifications in the brain corresponding to calcified cysticerci. Similar lesions were found in the muscles of the thighs and left lower leg. After another 18 years without cerebral symptoms these calcifications were demonstrated in CT.

[Intramedullary metastasis of pulmonary carcinoma].

An autopsied case of intramedullary metastasis of microcellular pulmonary carcinoma is described. Data of the incidence and clinical course of intramedullary metastases are presented.

[Thoracic radiation myelopathy].

In a 62-year-old patient 8 month after radiotherapy for right pulmonary hilus carcinoma signs of thoracis cord involvement with ascending course from Th10 to Th7. Cerebrospinal fluid and myelogram were normal. The patient died after about 12 months.

[Subacute sclerosing panencephalitis pregnancy].

In a patient aged 16 behaviour at changes, followed by visual agnosia, aphasia, paraparesis and involuntary movements developed about the 24th week of pregnancy. The presence of measles virus antibodies in the cerebrospinal fluid and progressing course of the disease with fever suggested SSPE. Pregnancy was terminated by caesarean section in the 30th week of pregnancy, the male premature baby died after 4 days, his brain was not examined under microscope.

[Brain lesions after radiotherapy].

On the basis of literature reports up to 1988 the incidence, clinical pattern and treatment of cerebral complications following radiotherapy administered to the organs and tissues of the head are discussed. Acute radiation-induced reaction and early delayed reaction in the form of e.g.

[Hoffmann's syndrome. The role of neurologists in the diagnosis of hypothyroidism].

In a mason aged 48 years gradually hardness, rigidity and painful muscle spasms, slowness of movements and awkwardness with progressing difficulties in walking developed. Only after several months of observation the finding of pseudo-myotonia suggested the diagnosis of Hoffmann's syndrome during hypothyroidism. In a number of neurological syndromes and in unclear muscular signs it is useful to consider hypothyroidism in the differential diagnosis.

On the mechanisms of ATP-induced and succinate-induced redistribution of cations in isolated rat liver cells.

1. The ability of external ATP to induce calcium uptake in isolated rat liver cells was further characterized. Stimulation of calcium uptake was specific for ATP, other nucleotides or ATP metabolites had no comparable effect.

[Many-year course of systemic lupus erythematosus with cerebral symptoms].

During 20 years of disease duration in the reported woman aged 47 years at the time of death articular involvement was followed by cardiac involvement and after labour renal signs appeared. Cerebral signs developed about 11 years before her death and manifested themselves as several typical strokes. The observed systemic affections, including the neurological signs, responded favourably to immunosuppression.

[Ataxic form of Jakob-Creutzfeldt syndrome].

The authors describe a man aged 43 years with a typical onset of the disease with cerebellar signs and progressive dementia prevailing during a 4 month course of the illness. Neuropathological examination demonstrated subacute spongiform encephalopathy with significant although not overwhelming damage to the cerebellar cortex. The case is an example of the ataxic form of this disease isolated in 1965.

[Ocular manifestations of myotonia atrophica].

In a 55-year-old male with a history of over 20 years of exposure to lead clinical, electromyographic and histological investigations demonstrated myotonic dystrophy. Cataract and high-grade concentric narrowing of the visual field were found bilaterally. The latter change has been reported sporadically in this disease.

[Neurological syndromes in the course of systemic lupus erythematosus].

Seven cases of SLE with concomitant neurological syndromes are reported. In 2 cases brain stroke with right-sided hemiplegia and aphasia developed, in the remaining cases brain-stem stroke with subarachnoid haemorrhage, progressive hemiparesis and signs of intracranial hypertension, chorea, status epilepticus in terminal uraemia were observed. In one case myasthenia coexisted.

[Isolated temporary pharyngeal paralysis in childhood. Viral neuroinfection with a mild course?].

The authors describe a boy aged 14 years who had identical signs as those described in 1976 in cases of isolated temporary pharyngeal paralysis (Edin et al). In this syndrome Sullivan and Carlson (1976) observed a rise in the titre of antibodies to Herpes simplex virus, and Nussey (1977) found in it infection caused by Coxsackie type A9 virus. In the presently reported case full serological and virological investigations were not done.

[Statistical analysis of mortality from stroke in hospitalized patients].

The authors analysed mortality from brain strokes in 1366 patients hospitalized at the Department of Neurology, Silesian Medical Academy in Katowice and Zabrze and in the 8th Municipal Hospital in Katowice in the years 1970--1974. The number of cases with lethal outcome was 437. The mortality was highest in cases of cerebral haemorrhages, particularly in women.