Publications by authors named "Kasper L Wethelund"
Objective: Targeted mild hypercapnia is a potential neuroprotective therapy after cardiac arrest. In this exploratory observational study, we aimed to explore the effects of targeted mild hypercapnia on cerebral microvascular resistance assessed by middle cerebral artery pulsatility index (MCA PI) and intracranial pressure estimated by optic nerve sheath diameter (ONSD) in resuscitated out-of-hospital cardiac arrest (OHCA) patients.
Design Setting Participants And Interventions: Comatose adults resuscitated from OHCA were randomly allocated to targeted mild hypercapnia (PaCO 50-55 mmHg) or targeted normocapnia (PaCO 35-45 mmHg) for 24 h in the TAME trial.
Article Synopsis
- * Results showed that as PEEP increased, measures of left ventricle pressure-volume area decreased significantly, indicating improved heart function in both healthy and CS states.
- * Although mean arterial pressure dropped with higher PEEP, cardiac output was maintained during LV-CS, suggesting that increasing PEEP could be a beneficial strategy in managing this condition.