Publications by authors named "Kaspar van den Dries"
Article Synopsis
- Dry powder mixing is important in the pharmaceutical industry, and the use of in-line Near Infrared (NIR) Spectroscopy is becoming more common for monitoring Blend Uniformity (BU), although it still faces challenges in routine application.
- A new qualitative approach to NIR-BU is introduced that simplifies the process without heavy calibration or method maintenance, using a moving F-test to determine the mixing endpoint.
- The method has been successfully used in commercial production for a low-dose product over five years, demonstrating its effectiveness and compliance with regulatory standards during over 100 batches.
Qualitative proof of liquid dispersion and penetration-involved granule formation in a high shear mixer.
Eur J Pharm Biopharm
November 2004
The origination of granules in the early seconds is an important aspect of high shear granulation. To elucidate these mechanisms, a substandard amount (1.5% w/w) of an aqueous hydroxypropyl cellulose solution was added to four different lactose mixtures: (1) lactose 100 M (d(4,3) approximately 170 microm), (2) lactose 200 M (d(4,3) approximately 50 microm), and (3, 4) 10% magnesium stearate/lactose 100 or 200 M.
View Article and Find Full Text PDFWet granulation of a powder mixture often leads to accumulation of the smallest particles in the large granules. The preferential uptake of these particles results in an inhomogeneous granulate. The aim of this study was to investigate the mechanism of preferential growth.
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