Publications by authors named "Kasirapat Ariya-Anandech"
is an important pathogen causing invasive infection associated with a high mortality rate. One mechanism that causes the failure of eradication is an increase in regulatory T cells (Treg), which play a major role in immune suppression and promoting pathogenicity. To date, how induces a Treg response remains unclear.
View Article and Find Full Text PDFPolymeric Particle BAM15 Targeting Macrophages Attenuates the Severity of LPS-Induced Sepsis: A Proof of Concept for Specific Immune Cell-Targeted Therapy.
Pharmaceutics
November 2023
Article Synopsis
- The study investigates how altering energy sources in macrophages can influence their functions, specifically in the context of severe inflammatory diseases like sepsis.
- Researchers found that the mitochondrial uncoupling agent BAM15 significantly affected M1 macrophage polarization without impacting M2 polarization, suggesting a targeted therapeutic potential.
- Using BAM15-loaded particles showed better results in reducing inflammation and liver injury in sepsis models, highlighting the effectiveness of a macrophage-specific delivery system for treating severe inflammatory conditions.
Dendritic cells (DCs) are the most potent antigen-presenting cells that have multifaceted functions in the control of immune activation and tolerance. Hyperresponsiveness and altered tolerogenicity of DCs contribute to the development and pathogenesis of system lupus erythematosus (SLE); therefore, DC-targeted therapies aimed at inducing specific immune tolerance have become of great importance for the treatment of SLE. This study developed a new nanoparticle (NP) containing a biodegradable PDMAEMA-PLGA copolymer for target-oriented delivery to DCs in situ.
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